Literature summary for 3.4.21.5 extracted from

De Filippis, V.; De Dea, E.; Lucatello, F.; Frasson, R.
Effect of Na+ binding on the conformation, stability and molecular recognition properties of thrombin (2005), Biochem. J., 390, 485-492.

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Activating Compound

Activating Compound	Comment	Organism	Structure
Na+	binding of Na+ serves to stabilize the enzyme in a more open and rigid conformation. Na+-bound enzyme is more stable to denaturation by urea and more resistant to limited proteolysis by subtilisin	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P00734	commercial preparation	-

Renatured (Commentary)

Renatured (Comment)	Organism
denaturation by urea, 60% reversible at pH 8.0, completely reversible at pH 6.5. Na+-bound form of enzyme is more stable to urea denaturation than Na+-free form by 2 kcal/mol	Homo sapiens

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Release 2023.1 (January 2023)