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Literature summary for 3.4.21.5 extracted from

  • Mourao, P.A.; Boisson-Vidal, C.; Tapon-Bretaudiere, J.; Drouet, B.; Bros, A.; Fischer, A.
    Inactivation of thrombin by a fucosylated chondroitin sulfate from echinoderm (2001), Thromb. Res., 102, 167-176.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
antithrombin enhances the inhibitory effect of thrombin inhibitors Homo sapiens
chondroitin 6-sulfate low inhibitory potential in anticoagulation assay Homo sapiens
fucosylated chondroitin sulfate from sea cucumber Ludwigothurea grisea, chemical composition, native or desulfated, carboxyl-reduced, or defucosylated, inhibitory potential in anticoagulation assay, overview, presence of antithrombin or heparin cofactor II is required for inhibition, inhibition of thrombin generation by thromboplastin Homo sapiens
heparin unfractionated, high inhibitory potential in anticoagulation assay, inhibition of thrombin generation by thromboplastin Homo sapiens
heparin cofactor II enhances the inhibitory effect of thrombin inhibitors Homo sapiens
sulfated fucan from brown seaweed Ascophylum nodosum, chemical composition, inhibitory potential in anticoagulation assay, inhibition of thrombin generation by thromboplastin Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-phenylalanyl-pipecolyl-L-arginine-4-nitroanilide + H2O i.e. S2238, synthetic chromogenic substrate Homo sapiens D-phenylalanyl-pipecolyl-L-arginine + 4-nitroaniline
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
assay at room temperature Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information
-
Homo sapiens