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Literature summary for 3.4.21.5 extracted from

  • Meh, D.A.; Siebenlist, K.R.; Brennan, S.O.; Holyst, T.; Mosesson, M.W.
    The amino acid sequence in fibrin responsible for high affinity thrombin binding (2001), Thromb. Haemost., 85, 470-474.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
factor VIII(716-731) peptide thrombin binding sequence is GDYYEDSYEDISAYLL, competitive Homo sapiens
fibrin gamma'-peptides sulfated and non-sulfated peptide sequences of the gamma'-chains of human fibrin 1 and 2, overview, competitive Homo sapiens
fibrinogen gamma'(408-427) peptide of the gamma'-domain, thrombin binding sequence is VRPEHPAETEYDSLYPEDDL, competitive Homo sapiens
hirudin(53-64) peptide thrombin binding sequence is NGDFEEIPEEYL, competitive Homo sapiens
human GPIBalpha(269-287) peptide thrombin binding sequence is DEGDTDLYDYYPEEDTEGD, competitive Homo sapiens
human heparin cofactor II(56-75) peptide thrombin binding sequences are GEEDDDYLDLE and EDDDYIDIVD, competitive Homo sapiens
human PAR1(52-69) peptide thrombin binding sequence is YEPFWEDEEKNESGLTEY, competitive Homo sapiens
Phe-Pro-Arg-chloromethyl ketone i.e. PPACK Homo sapiens
thrombomodulin(408-426) peptide thrombin binding sequence is GDYYEDSYEDISAYLL, competitive Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36500
-
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibrinogen 1 + H2O Homo sapiens
-
fibrin 1 + fibrinopeptide A + fibrinopeptide B
-
?
fibrinogen 2 + H2O Homo sapiens
-
fibrin 2 + fibrinopeptide A + fibrinopeptide B
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fibrinogen 1 + H2O
-
Homo sapiens fibrin 1 + fibrinopeptide A + fibrinopeptide B
-
?
fibrinogen 1 + H2O human, composed of 2 gamma-chains, gamma A and gamma' Homo sapiens fibrin 1 + fibrinopeptide A + fibrinopeptide B fibrin 1 contains a low affinity binding site in the E doamin, and a high affinity binding site at residues 408-427 of the gamma'-chain, sequence VRPEHPAETEYDSLYPEDDL, for thrombin exosites, binding study, overview ?
fibrinogen 2 + H2O
-
Homo sapiens fibrin 2 + fibrinopeptide A + fibrinopeptide B
-
?
fibrinogen 2 + H2O human, composed of 2 gamma-chains, gamma A and gamma' Homo sapiens fibrin 2 + fibrinopeptide A + fibrinopeptide B fibrin 2 contains a low affinity binding site in the E doamin, and a high affinity binding site at residues 408-427 of the gamma'-chain, sequence VRPEHPAETEYDSLYPEDDL, for thrombin exosites, binding study, overview ?

Synonyms

Synonyms Comment Organism
alpha-thrombin
-
Homo sapiens