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Literature summary for 3.4.21.43 extracted from
- Aurin tricarboxylic acid self-protects by inhibiting aberrant complement activation at the C3 convertase and C9 binding stages (2013), Neurobiol. Aging, 34, 1451-1461.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| zymosan | it is capable of activating the classical pathway as well as the alternative pathway, when the classical pathway is blocked, mechanism, overview | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| C1 inhibitor | blocks the the classical pathway | Homo sapiens | |
| C4d antibody | blocks the the classical pathway | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| C3 convertase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | zymosan activates the classical pathway by an antigen-antibody reaction in normal human serum requiring IgG and IgM antibodies, it cannot initiate classical pathway activation without the antibodies, regulation, overview | Homo sapiens |
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Release 2023.1 (January 2023)
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