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Literature summary for 3.4.21.35 extracted from

  • Liu, L.; Zhang, R.; Liu, K.; Zhou, H.; Yang, X.; Liu, X.; Tang, M.; Su, J.; Dong, Q.
    Tissue kallikrein protects cortical neurons against in vitro ischemia-acidosis/reperfusion-induced injury through the ERK1/2 pathway (2009), Exp. Neurol., 219, 453-465.
    View publication on PubMed
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Application

Application Comment Organism
drug development tissue kallikrein represents a promising therapeutic strategy for ischemic stroke Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
urine
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
kallidinogenase
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 Homo sapiens
tissue kallikrein
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 Homo sapiens

General Information

General Information Comment Organism
physiological function tissue kallikrein has antioxidant characteristics and is capable of alleviating ischemia-acidosis/reperfusion-induced injury, inhibiting apoptosis and promoting cell survival in vitro: pretreatment of cultured cortical neurons from rats with tissue kallikrein reduces cell death induced by either acidosis or oxygen and glucose deprivation-acidosis/reoxygenation. It exerts the neuroprotective effects by reducing production of reactive oxygen species, stabilizing the mitochondrial membrane potential and inhibiting caspase-3 activation, and thereby attenuating oxidative stress and apoptosis. Activation of the extracellular signal-regulated kinase1/2 signaling cascade but not the PI3K/Akt signaling pathway is required for the survival-promoting effect of tissue kallikrein on neurons exposed to oxygen and glucose deprivation-acidosis/reoxygenation Homo sapiens