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Literature summary for 3.4.21.35 extracted from

  • Matsui, H.; Takano, N.; Takahashi, T.
    Characterization of mouse glandular kallikrein 24 expressed in testicular Leydig cells (2005), Int. J. Biochem. Cell Biol., 37, 2333-2343.
    View publication on PubMed
Search for more literature for 3.4.21.35

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
antipain 0.1 mM, 90% inhibition of hydrolysis of Pro-Phe-Arg-4-methylcoumarin-7-amide Mus musculus
Aprotinin 0.1 mM, 55% inhibition of hydrolysis of Pro-Phe-Arg-4-methylcoumarin-7-amide Mus musculus
benzamidine 1 mM, 80% inhibition of hydrolysis of Pro-Phe-Arg-4-methylcoumarin-7-amide Mus musculus
chymostatin 0.01 mM, 5% inhibition of hydrolysis of Pro-Phe-Arg-4-methylcoumarin-7-amide Mus musculus
diisopropylfluorophosphate 2.0 mM, complete inhibition of hydrolysis of Pro-Phe-Arg-4-methylcoumarin-7-amide Mus musculus
leupeptin 0.1 mM, about 75% inhibition of hydrolysis of Pro-Phe-Arg-4-methylcoumarin-7-amide; 0.2 mM, 85% inhibition of hydrolysis of Pro-Phe-Arg-4-methylcoumarin-7-amide Mus musculus
Nalpha-p-tosyl-L-lysine chloromethyl ketone 0.1 mM, 10% inhibition of hydrolysis of Pro-Phe-Arg-4-methylcoumarin-7-amide Mus musculus
Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone 0.1 mM, 5% inhibition of hydrolysis of Pro-Phe-Arg-4-methylcoumarin-7-amide Mus musculus
pepstatin 0.01 mM, 10% inhibition of hydrolysis of Pro-Phe-Arg-4-methylcoumarin-7-amide Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus kallikrein 24 may play a role in the degradation of extracellular matrix proteins in the interstitial area surrounding the Leydig cells of the adult mouse testis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epididymis
-
 Mus musculus
-
kidney
-
 Mus musculus
-
ovary
-
 Mus musculus
-
submandibular gland
-
 Mus musculus
-
testis expressed exclusively in the Leydig cells of adult mice Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O about 30% of the activity with Pro-Phe-Arg-4-methylcoumarin 7-amide Mus musculus ?
-
 ?
casein + H2O
-
 Mus musculus ?
-
 ?
Fibronectin + H2O
-
 Mus musculus ?
-
 ?
Gelatin + H2O
-
 Mus musculus ?
-
 ?
Laminin + H2O
-
 Mus musculus ?
-
 ?
additional information kallikrein 24 may play a role in the degradation of extracellular matrix proteins in the interstitial area surrounding the Leydig cells of the adult mouse testis Mus musculus ?
-
 ?
Pro-Phe-Arg-4-methylcoumarin 7-amide + H2O
-
 Mus musculus ?
-
 ?
tert-butyloxycarbonyl-Gln-Ala-Arg-4-methylcoumarin 7-amide + H2O about 15% of the activity with Pro-Phe-Arg-4-methylcoumarin 7-amide Mus musculus ?
-
 ?
tert-butyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O about 50% of the activity with Pro-Phe-Arg-4-methylcoumarin 7-amide Mus musculus ?
-
 ?
tert-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin + H2O about 20% of the activity with Pro-Phe-Arg-4-methylcoumarin 7-amide Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
kallikrein 24
-
 Mus musculus