Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Aprotinin | - |
Homo sapiens | |
Cd2+ | - |
Homo sapiens | |
Human plasma | - |
Homo sapiens | |
human urine | - |
Homo sapiens | |
kallikrein antibody | - |
Homo sapiens | |
Na+ | inhibits amidase activity | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
12.7 | - |
human low molecular weight kininogen | pH 7.8, 37°C | Homo sapiens | |
17.6 | - |
human high molecular weight kininogen | pH 7.8, 37°C | Homo sapiens | |
28.4 | - |
D-Val-Leu-Arg-p-nitroanilide | pH 7.8, 37°C | Homo sapiens | |
50.8 | - |
citrated dog plasma | pH 7.8, 37°C | Homo sapiens | |
61.1 | - |
citrated bovine plasma | pH 7.8, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | secretion | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Na+ | required for kininogenase activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
polypeptide + H2O | Homo sapiens | - |
peptides | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
397fold | Homo sapiens |
large scale | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
urine | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
citrated bovine plasma + H2O | - |
Homo sapiens | ? | - |
? | |
citrated dog plasma + H2O | - |
Homo sapiens | ? | - |
? | |
D-Val-Leu-Arg-p-nitroanilide + H2O | - |
Homo sapiens | D-Val-Leu-Arg + p-nitroaniline | - |
? | |
human high molecular weight kininogen + H2O | - |
Homo sapiens | ? | - |
? | |
kininogen + H2O | high molecular weight kininogen from human and rat | Homo sapiens | kinin + ? | - |
? | |
low-molecular-weight kininogen + H2O | human | Homo sapiens | kallidin + kinin | - |
? | |
polypeptide + H2O | - |
Homo sapiens | peptides | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.8 | - |
assay at | Homo sapiens |