Literature summary for 3.4.21.34 extracted from

Storini, C.; Bergamaschini, L.; Gesuete, R.; Rossi, E.; Maiocchi, D.; De Simoni, M.G.
Selective inhibition of plasma kallikrein protects brain from reperfusion injury (2006), J. Pharmacol. Exp. Ther., 318, 849-854.

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Application

Application	Comment	Organism
medicine	DX-88 has a strong neuroprotective effect in the early phases of brain ischemia preventing reperfusion injury and indicates that inhibition of plasma kallikrein may be useful tool in the strategy aimed at reducing the detrimental effects linked to reperfusion	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
DX-88	DX-88 has a strong neuroprotective effect in the early phases of brain ischemia preventing reperfusion injury and indicates that inhibition of plasma kallikrein may be useful tool in the strategy aimed at reducing the detrimental effects linked to reperfusion	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

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Release 2023.1 (January 2023)