Activating Compound | Comment | Organism | Structure |
---|---|---|---|
factor XIIa | activation by cleavage into light- and heavy-chain, that are linked by one or more disulfide bridges after cleavage | Homo sapiens | |
factor XIIa | activation by cleavage into light- and heavy-chain, that are linked by one or more disulfide bridges after cleavage | Rattus norvegicus | |
factor XIIa | activation by cleavage into light- and heavy-chain, that are linked by one or more disulfide bridges after cleavage | Mus musculus | |
additional information | binding to negatively charged surfaces activates the enzyme | Homo sapiens | |
additional information | binding to negatively charged surfaces activates the enzyme | Rattus norvegicus | |
additional information | binding to negatively charged surfaces activates the enzyme | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | plasma | Homo sapiens | - |
- |
soluble | plasma | Rattus norvegicus | - |
- |
soluble | plasma | Mus musculus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor XII + H2O | Homo sapiens | activation of the factor XII, bound to negatively charged surfaces | ? | - |
ir | |
factor XII + H2O | Rattus norvegicus | activation of the factor XII, bound to negatively charged surfaces | ? | - |
ir | |
factor XII + H2O | Mus musculus | activation of the factor XII, bound to negatively charged surfaces | ? | - |
ir | |
kininogen + H2O | Homo sapiens | high-molecular weight kininogen | bradykinin + fragments of kininogen | - |
ir | |
kininogen + H2O | Rattus norvegicus | high-molecular weight kininogen | bradykinin + fragments of kininogen | - |
ir | |
kininogen + H2O | Mus musculus | high-molecular weight kininogen | bradykinin + fragments of kininogen | - |
ir | |
additional information | Homo sapiens | defects in gene KLKB1 cause Fletcher factor deficiency, a blood coagulation defect | ? | - |
? | |
Prorenin + H2O | Homo sapiens | activation of prorenin, involved in the renin-angiotensin system | Renin + ? | - |
ir | |
Prorenin + H2O | Rattus norvegicus | activation of prorenin, involved in the renin-angiotensin system | Renin + ? | - |
ir | |
Prorenin + H2O | Mus musculus | activation of prorenin, involved in the renin-angiotensin system | Renin + ? | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P03952 | gene KLK3 or KLKB1, plasma kallikrein precursor | - |
Mus musculus | P26262 | gene KLKB1 or KLK3 or PK, plasma kallikrein precursor | - |
Rattus norvegicus | P14272 | gene KLKB1 or PK, plasma kallikrein precursor | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasma | - |
Homo sapiens | - |
plasma | - |
Rattus norvegicus | - |
plasma | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor XII + H2O | activation of the factor XII, bound to negatively charged surfaces | Homo sapiens | ? | - |
? | |
factor XII + H2O | activation of the factor XII, bound to negatively charged surfaces | Homo sapiens | ? | - |
ir | |
factor XII + H2O | activation of the factor XII, bound to negatively charged surfaces | Rattus norvegicus | ? | - |
? | |
factor XII + H2O | activation of the factor XII, bound to negatively charged surfaces | Rattus norvegicus | ? | - |
ir | |
factor XII + H2O | activation of the factor XII, bound to negatively charged surfaces | Mus musculus | ? | - |
? | |
factor XII + H2O | activation of the factor XII, bound to negatively charged surfaces | Mus musculus | ? | - |
ir | |
kininogen + H2O | high-molecular weight kininogen | Homo sapiens | bradykinin + fragments of kininogen | - |
? | |
kininogen + H2O | high-molecular weight kininogen | Homo sapiens | bradykinin + fragments of kininogen | - |
ir | |
kininogen + H2O | high-molecular weight kininogen | Rattus norvegicus | bradykinin + fragments of kininogen | - |
? | |
kininogen + H2O | high-molecular weight kininogen | Rattus norvegicus | bradykinin + fragments of kininogen | - |
ir | |
kininogen + H2O | high-molecular weight kininogen | Mus musculus | bradykinin + fragments of kininogen | - |
ir | |
kininogen + H2O | human high-molecular weight kininogen | Mus musculus | bradykinin + fragments of kininogen | - |
? | |
additional information | belongs to the peptidase family S1, plasma kallikrein subfamily | Homo sapiens | ? | - |
? | |
additional information | belongs to the peptidase family S1, plasma kallikrein subfamily | Rattus norvegicus | ? | - |
? | |
additional information | belongs to the peptidase family S1, plasma kallikrein subfamily | Mus musculus | ? | - |
? | |
additional information | defects in gene KLKB1 cause Fletcher factor deficiency, a blood coagulation defect | Homo sapiens | ? | - |
? | |
Prorenin + H2O | activation of prorenin | Homo sapiens | Renin + ? | - |
ir | |
Prorenin + H2O | activation of prorenin | Rattus norvegicus | Renin + ? | - |
ir | |
Prorenin + H2O | activation of prorenin | Mus musculus | Renin + ? | - |
ir | |
Prorenin + H2O | activation of prorenin, involved in the renin-angiotensin system | Homo sapiens | Renin + ? | - |
ir | |
Prorenin + H2O | activation of prorenin, involved in the renin-angiotensin system | Rattus norvegicus | Renin + ? | - |
ir | |
Prorenin + H2O | activation of prorenin, involved in the renin-angiotensin system | Mus musculus | Renin + ? | - |
ir |