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Literature summary for 3.4.21.21 extracted from

  • Eriksson, O.; Ramstroem, M.; Hoernaeus, K.; Bergquist, J.; Mokhtari, D.; Siegbahn, A.
    The Eph tyrosine kinase receptors EphB2 and EphA2 are novel proteolytic substrates of tissue factor/coagulation factor VIIa (2014), J. Biol. Chem., 289, 32379-32391.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
tissue factor
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Eph tyrosine kinase receptor EphA2 + H2O Homo sapiens cleavage site at the Arg159-His160 bond ?
-
?
Eph tyrosine kinase receptor EphB2 + H2O Homo sapiens cleavage site at the Arg159-His160 bond ?
-
?
protease-activated receptor 2 + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Eph tyrosine kinase receptor EphA2 + H2O cleavage site at the Arg159-His160 bond Homo sapiens ?
-
?
Eph tyrosine kinase receptor EphB2 + H2O cleavage site at the Arg159-His160 bond Homo sapiens ?
-
?
protease-activated receptor 2 + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
factor VIIa
-
Homo sapiens
FVIIa
-
Homo sapiens

General Information

General Information Comment Organism
physiological function FVIIa causes potentiation of cell repulsion by the Eph tyrosine kinase receptor EphB2 ligand ephrin-B1, demonstrating a proteolytical event to control Eph-mediated cell segregation Homo sapiens