Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.21 extracted from

  • Andersen, L.M.; Andreasen, P.A.; Svendsen, I.; Keemink, J.; ?stergaard, H.; Persson, E.
    Antibody-induced enhancement of factor VIIa activity through distinct allosteric pathways (2012), J. Biol. Chem., 287, 8994-9001.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.21

Activating Compound

Activating Compound Comment Organism Structure
additional information the relative catalytic efficiency is increased 170 and 150fold in the presence of saturating amounts of monoclonal antibodies F36 and F37, respectively Homo sapiens
tissue factor in the absence of its cofactor tissue factor, coagulation factor VIIa predominantly exists in a zymogen-like, catalytically incompetent state Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-aminobenzamidine
-
 Homo sapiens
D-Phe-Phe-Arg chloromethyl ketone
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0054
-
 Factor X in 50 mM HEPES, pH 7.4, with 0.1 M NaCl, 5 mM CaCl2, 0.1% (w/v) bovine serum albumin, and 0.01% Tween 80, at 25°C Homo sapiens
11.8
-
 S-2288 in 50 mM HEPES, pH 7.4, with 0.1 M NaCl, 5 mM CaCl2, 0.1% (w/v) bovine serum albumin, and 0.01% Tween 80, at 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Factor X + H2O Homo sapiens
-
 Factor Xa + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Factor X + H2O
-
 Homo sapiens Factor Xa + ?
-
 ?
S-2288 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
activated coagulation factor VII
-
 Homo sapiens
factor VIIa
-
 Homo sapiens
FVIIa
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.00001
-
 Factor X in 50 mM HEPES, pH 7.4, with 0.1 M NaCl, 5 mM CaCl2, 0.1% (w/v) bovine serum albumin, and 0.01% Tween 80, at 25°C Homo sapiens
13
-
 S-2288 in 50 mM HEPES, pH 7.4, with 0.1 M NaCl, 5 mM CaCl2, 0.1% (w/v) bovine serum albumin, and 0.01% Tween 80, at 37°C Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.2
-
 4-aminobenzamidine in 50 mM HEPES, pH 7.4, with 0.1 M NaCl, 5 mM CaCl2, 0.1% (w/v) bovine serum albumin, and 0.01% Tween 80, at 25°C Homo sapiens