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Literature summary for 3.4.21.21 extracted from

  • Soeda, T.; Nogami, K.; Matsumoto, T.; Ogiwara, K.; Shima, M.
    Mechanisms of factor VIIa-catalyzed activation of factor VIII (2010), J. Thromb. Haemost., 8, 2494-2503.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
tissue factor
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor VIII + H2O Homo sapiens FVIII activity increases about 4-fold within 30 s in the presence of FVIIa/tissue factor. The heavy chain of FVIII is proteolyzed at Arg336. Arg740 and Arg372 factor VIIIa + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor VIII + H2O FVIII activity increases about 4-fold within 30 s in the presence of FVIIa/tissue factor. The heavy chain of FVIII is proteolyzed at Arg336. Arg740 and Arg372 Homo sapiens factor VIIIa + ?
-
?

Synonyms

Synonyms Comment Organism
factor VIIa
-
Homo sapiens
FVIIa
-
Homo sapiens