Protein Variants | Comment | Organism |
---|---|---|
D72N | the mutant shows 13% of wild type FVIIa signaling activity towards protease-activated receptor 2 | Homo sapiens |
Q143N | the mutant reduces interleukin-8 expression to background levels but maintains essentially normal pro-coagulant activity | Homo sapiens |
Q217E | the mutant shows enhanced protease-activated receptor 2 activation | Homo sapiens |
Q40A | the mutant reduces interleukin-8 expression to background levels but maintains essentially normal pro-coagulant activity | Homo sapiens |
T151A | the mutant shows 13% of wild type FVIIa signaling activity towards protease-activated receptor 2 | Homo sapiens |
T151S | the variant activates macromolecular coagulation substrates and supports signaling of the ternary tissue factor-FVIIa-Xa complex normally but is severely impaired in binary tissue factor-FVIIa-protease-activated receptor 2 signaling | Homo sapiens |
T99A | the mutant shows 17% of wild type FVIIa signaling activity towards protease-activated receptor 2 | Homo sapiens |
T99Y | the mutation leads to enhanced protease-activated receptor 2 activation (2-3fold above the wild type FVIIa activity) | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor IX + H2O | Homo sapiens | FVIIa catalyzes activation of factor X | factor IXa + ? | - |
? | |
Factor X + H2O | Homo sapiens | FVIIa catalyzes activation of factor X | Factor Xa + ? | - |
? | |
protease-activated receptor 2 + H2O | Homo sapiens | protease-activated receptor 2 is cleaved by FVIIa in the binary tissue factor-FVIIa complex | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor IX + H2O | FVIIa catalyzes activation of factor X | Homo sapiens | factor IXa + ? | - |
? | |
Factor X + H2O | FVIIa catalyzes activation of factor X | Homo sapiens | Factor Xa + ? | - |
? | |
protease-activated receptor 2 + H2O | protease-activated receptor 2 is cleaved by FVIIa in the binary tissue factor-FVIIa complex | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
factor VIIa | - |
Homo sapiens |
FVIIa | - |
Homo sapiens |