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Literature summary for 3.4.21.21 extracted from

  • Ohkubo, Y.Z.; Tajkhorshid, E.
    Distinct structural and adhesive roles of Ca2+ in membrane binding of blood coagulation factors (2008), Structure, 16, 72-81.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
vitamin K dependent on Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane Ca2+ and the Gla domain are required for membrane binding by the enzyme, mechanism of Ca2+-mediated binding, molecular dynamics simulation of complex formation, overview Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on, eight Ca2+ are bound via the Gla domain and involved in enzyme binding to the membrane with different tasks, structure and coordination, mechanism of Ca2+-mediated binding, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens membrane binding constitutes a key process in enzymatic activation of various blood coagulation factors ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information membrane binding constitutes a key process in enzymatic activation of various blood coagulation factors Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
More Ca2+ and the Gla domain are required for membrane binding by the enzyme involving residues R9, R15, K18, R28, K32, R36, and K38, molecular dynamics simulation of complex formation, structure, overview Homo sapiens

Synonyms

Synonyms Comment Organism
FVIIa
-
Homo sapiens