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Literature summary for 3.4.21.21 extracted from

  • Ahamed, J.; Versteeg, H.H.; Kerver, M.; Chen, V.M.; Mueller, B.M.; Hogg, P.J.; Ruf, W.
    Disulfide isomerization switches tissue factor from coagulation to cell signaling (2006), Proc. Natl. Acad. Sci. USA, 103, 13932-13937.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
tissue factor cell-surface tissue factor TF binds the serine protease factor VIIa to activate coagulation or, alternatively, to trigger signaling through the G protein-coupled, protease-activated receptor 2 relevant to inflammation and angiogenesis, extracellular Cys186-Cys209 disulfide bond of TF is critical for coagulation, overview, mutant TF C209A with an unpaired Cys186 retains TF-VIIa signaling activity, and it has reduced affinity for VIIa, regulation, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens cell-surface tissue factor TF binds the serine protease factor VIIa to activate coagulation or, alternatively, to trigger signaling through the G protein-coupled, protease-activated receptor 2 relevant to inflammation and angiogenesis, TF-VIIa-mediated coagulation and cell signaling involve distinct cellular pools of TF, regulation, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cell-surface tissue factor TF binds the serine protease factor VIIa to activate coagulation or, alternatively, to trigger signaling through the G protein-coupled, protease-activated receptor 2 relevant to inflammation and angiogenesis, TF-VIIa-mediated coagulation and cell signaling involve distinct cellular pools of TF, regulation, overview Homo sapiens ?
-
?