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Literature summary for 3.4.21.122 extracted from

  • Kuehn, N.; Bergmann, S.; Koesterke, N.; Lambertz, R.L.O.; Keppner, A.; van den Brand, J.M.A.; Poehlmann, S.; Weiss, S.; Hummler, E.; Hatesuer, B.; Schughart, K.
    The proteolytic activation of (H3N2) influenza A virus hemagglutinin is facilitated by different type II transmembrane serine proteases (2016), J. Virol., 90, 4298-4307 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus Q9JIQ8
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Source Tissue

Source Tissue Comment Organism Textmining
alveolar cell type I Tmprss2 and Tmprss4 are coexpressed in alveolar and bronchial regions Mus musculus
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alveolar cell type II Tmprss2 and Tmprss4 are coexpressed in alveolar and bronchial regions Mus musculus
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bronchus Tmprss2 and Tmprss4 are coexpressed in alveolar and bronchial regions Mus musculus
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General Information

General Information Comment Organism
physiological function after infection of Tmprss2 knockout mice with an H3N2 influenza virus, only a slight increase in survival is observed. Tmprss2-/- Tmprss4-/-x02double-knockout mice show a remarkably reduced virus spread and lung pathology, in addition to reduced body weight loss and mortality Mus musculus