Cloned (Comment) | Organism |
---|---|
gene KLK7, expression profiling in BxPC-3 cells from pancreatic adenocarcinomas | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
chymostatin | - |
Homo sapiens | |
additional information | phosphoramidon inhibits thermolysin and thus activation of pro-kallikrein 7 | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
E-cadherin + H2O | Homo sapiens | kallikrein 7 degrades extracellular matrix proteins, and enhances pancreatic cancer cell invasion by shedding E-cadherin, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene KLK7 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | activation of recombinant pro-kallikrein 7 by thermolysin, inhibited by phosphoramidon | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BxPC-3 cell | - |
Homo sapiens | - |
commercial preparation | recombinant pro-kallikrein 7 | Homo sapiens | - |
PANC-1 cell | - |
Homo sapiens | - |
pancreatic cancer cell | PCR expression profile of serine proteases from both healthy and malignant pancreatic tissues | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
cell aggregation assay using Panc-1 cells | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
E-cadherin + H2O | kallikrein 7 degrades extracellular matrix proteins, and enhances pancreatic cancer cell invasion by shedding E-cadherin, overview | Homo sapiens | ? | - |
? | |
E-cadherin + H2O | epithelial cell adhesion molecule | Homo sapiens | ? | - |
? | |
Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 + H2O | a fluorogenic peptide substrate | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
kallikrein 7 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8.5 | assay at | Homo sapiens |