Literature summary for 3.4.21.109 extracted from

Tseng, I.C.; Xu, H.; Chou, F.P.; Li, G.; Vazzano, A.P.; Kao, J.P.; Johnson, M.D.; Lin, C.Y.
Matriptase activation, an early cellular response to acidosis (2010), J. Biol. Chem., 285, 3261-3270.

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Activating Compound

Activating Compound	Comment	Organism	Structure
4,4'-diisothiocyanatostilbene-2,2' disulfonic acid	as an early response to acidosis, matriptase activation can also be induced by perturbation of intracellular pH homeostasis using substances inhibiting Na+/H+ exchangers or other acid-base ion channels	Homo sapiens
5-(N-ethyl-N-isopropyl)-amiloride	as an early response to acidosis, matriptase activation can also be induced by perturbation of intracellular pH homeostasis using substances inhibiting Na+/H+ exchangers or other acid-base ion channels	Homo sapiens
5-(N-methyl-N-isobutyl)-amiloride	as an early response to acidosis, matriptase activation can also be induced by perturbation of intracellular pH homeostasis using substances inhibiting Na+/H+ exchangers or other acid-base ion channels	Homo sapiens
H+	exposure of epithelial and carcinoma cells to a mildly acidic extracellular milieu pH 6.0 results in robust matriptase activation	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
hepatocyte growth factor activator inhibitor 1	following matriptase activation, the active enzyme is immediately inhibited by binding to hepatocyte growth factor activator inhibitor 1, resulting in stable matriptase-hepatocyte growth factor activator inhibitor 1 complexes that are rapidly secreted	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell surface	acid-induced matriptase activation takes place both on the cell surface and inside the cells, likely due to the parallel intracellular acidification that activates intracellular matriptase	Homo sapiens	9986	-
intracellular	acid-induced matriptase activation takes place both on the cell surface and inside the cells, likely due to the parallel intracellular acidification that activates intracellular matriptase	Homo sapiens	5622	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
70000	-	SDS-PAGE, reducing condition, and Western blot, latent form of matriptase	Homo sapiens
120000	-	SDS-PAGE, reducing condition, and Western blot, activated form of matriptase in complex with hepatocyte growth factor activator inhibitor 1	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
matriptase	-	Homo sapiens

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Release 2023.1 (January 2023)