Literature summary for 3.4.21.109 extracted from

Miyake, Y.; Yasumoto, M.; Tsuzuki, S.; Fushiki, T.; Inouye, K.
Activation of a membrane-bound serine protease matriptase on the cell surface (2009), J. Biochem., 146, 273-282.

Search for more literature for 3.4.21.109

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in COS-1 cells	Rattus norvegicus

Protein Variants

Protein Variants	Comment	Organism
S805A	active-site serine is mutated to alanine, no 28 kDa is produced form either medium or cell membrane samples when expressed in COS-1 cells, suggesting that activation cleavage of wild-type-matriptase in COS-1 cells occurs via a mechanism requiring its active site	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell surface	matriptase is activated when it reaches the cell surface	Rattus norvegicus	9986	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
28000	-	SDS-PAGE and Western blot analysis, reducing conditions, activated matriptase, disulfide-linked two-chain C-terminal fragment	Rattus norvegicus
90000	-	SDS-PAGE and Western blot analysis, reducing conditions, non-activated enzyme, single-chain C-terminal fragment	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	enzyme is post-translationally processed by cleavage between Gly149 and Ser150	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
matriptase	-	Rattus norvegicus

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Release 2023.1 (January 2023)