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Literature summary for 3.4.21.109 extracted from

  • Szabo, R.; Hobson, J.P.; List, K.; Molinolo, A.; Lin, C.Y.; Bugge, T.H.
    Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity (2008), J. Biol. Chem., 283, 29495-29504.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.109

Inhibitors

Inhibitors Comment Organism Structure
hepatocyte growth factor activator inhibitor-1 HAI-1 Homo sapiens
hepatocyte growth factor activator inhibitor-1 HAI-1 Mus musculus
hepatocyte growth factor activator inhibitor-2 HAI-2 Homo sapiens
hepatocyte growth factor activator inhibitor-2 HAI-2 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-urokinase-type plasminogen activator + H2O Mus musculus
-
 ?
-
 ?
pro-urokinase-type plasminogen activator + H2O Homo sapiens
-
 ?
-
 ?
prostatin + H2O Mus musculus
-
 ?
-
 ?
prostatin + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
antral follicle ovary Mus musculus
-
bile duct epithelium liver Mus musculus
-
cerebral cortex skin Mus musculus
-
collecting duct kidney Mus musculus
-
crypt jejunum, ileum, colon Mus musculus
-
epithelial cell
-
 Homo sapiens
-
epithelium esophagus and forestomach, suprabasal layer, trachea, bronchi, bronchioles, bladder Mus musculus
-
goblet cell colon Mus musculus
-
granulosa cell ovary Mus musculus
-
hair follicle inner root sheath skin Mus musculus
-
lip epithelium oral cavity Mus musculus
-
medulla oblongata skin Mus musculus
-
oral mucosa oral cavity Mus musculus
-
oxyntic cell glandular stomach Mus musculus
-
pancreatic islet pancreas Mus musculus
-
parotid gland duct epithelium
-
 Mus musculus
-
renal distal tubule kidney Mus musculus
-
renal proximal tubule kidney Mus musculus
-
sebaceous gland skin Mus musculus
-
stratum granulosum cerebelli skin Mus musculus
-
sublingual gland duct epithelium
-
 Mus musculus
-
submandibular gland duct epithelium
-
 Mus musculus
-
surface epithelium colon, uterus Mus musculus
-
THP-1 cell
-
 Homo sapiens
-
thymic medullary epithelium
-
 Mus musculus
-
tongue epithelium oral cavity Mus musculus
-
uterine gland uterus Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Glu-Gly-Arg-p-nitroanilide + H2O substrate activity assay Homo sapiens ?
-
 ?
pro-urokinase-type plasminogen activator + H2O
-
 Mus musculus ?
-
 ?
pro-urokinase-type plasminogen activator + H2O
-
 Homo sapiens ?
-
 ?
prostatin + H2O
-
 Mus musculus ?
-
 ?
prostatin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
matriptase
-
 Mus musculus
matriptase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 activity, inhibition assay Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 activity, inhibition assay Homo sapiens