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Literature summary for 3.4.21.109 extracted from

  • Beliveau, F.; Desilets, A.; Leduc, R.
    Probing the substrate specificities of matriptase, matriptase-2, hepsin and DESC1 with internally quenched fluorescent peptides (2009), FEBS J., 276, 2213-2226.
    View publication on PubMed
Search for more literature for 3.4.21.109

Cloned(Commentary)

Cloned (Comment) Organism
amino acids 596-855 are expressed in Escherichia coli cells Homo sapiens
for expression in Drosophila S2 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-(2-aminoethyl)-benzenesulfonylfluoride hydrochloride AEBSF Homo sapiens
alpha2-antiplasmin
-
 Homo sapiens
antithrombin III
-
 Homo sapiens
Aprotinin
-
 Homo sapiens
leupeptin
-
 Homo sapiens
plasminogen activator inhibitor I
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0033
-
 RRARVVGG
-
 Homo sapiens
0.012
-
 RRARVVGG
-
 Homo sapiens
0.018
-
 RQARAVGG
-
 Homo sapiens
0.03
-
 filaggrin
-
 Homo sapiens
0.046
-
 filaggrin
-
 Homo sapiens
0.05
-
 RQRRVVGG
-
 Homo sapiens
0.05
-
 RQYRVVGG
-
 Homo sapiens
0.052
-
 trask
-
 Homo sapiens
0.065
-
 RQARQVGG
-
 Homo sapiens
0.07
-
 trask
-
 Homo sapiens
0.088
-
 RLARVVGG
-
 Homo sapiens
0.1
-
 alphaEbeta7 integrin
-
 Homo sapiens
0.104
-
 matriptase
-
 Homo sapiens
0.104
-
 RQARVVGG
-
 Homo sapiens
0.111
-
 alphaEbeta7 integrin
-
 Homo sapiens
0.124
-
 RQLRVVGG
-
 Homo sapiens
0.126
-
 matriptase
-
 Homo sapiens
0.126
-
 RQARVVGG
-
 Homo sapiens
0.128
-
 RQARAVGG
-
 Homo sapiens
0.137
-
 RYARVVGG
-
 Homo sapiens
0.142
-
 protease-activated receptor-2
-
 Homo sapiens
0.159
-
 RAARVVGG
-
 Homo sapiens
0.197
-
 protease-activated receptor-2
-
 Homo sapiens
0.869
-
 RQARYVGG
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
29000
-
 amino acids 596-855, theoretical molecular mass Homo sapiens
84000
-
 calculated molecular mass Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens
by immobilized metal-chelate affinity chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alphaEbeta7 integrin + H2O
-
 Homo sapiens ?
-
 ?
filaggrin + H2O
-
 Homo sapiens ?
-
 ?
matriptase + H2O
-
 Homo sapiens ?
-
 ?
protease-activated receptor-2 + H2O
-
 Homo sapiens ?
-
 ?
RAARVVGG + H2O
-
 Homo sapiens RAAR + VVGG
-
 ?
RLARVVGG + H2O
-
 Homo sapiens RLAR + VVGG
-
 ?
RQARAVGG + H2O
-
 Homo sapiens RQAR + AVGG
-
 ?
RQARQVGG + H2O
-
 Homo sapiens RQAR + QVGG
-
 ?
RQARVVGG + H2O
-
 Homo sapiens RQAR + VVGG
-
 ?
RQARYVGG + H2O
-
 Homo sapiens RQAR + YVGG
-
 ?
RQLRVVGG + H2O
-
 Homo sapiens RQLR + VVGG
-
 ?
RQRRVVGG + H2O
-
 Homo sapiens RQRR + VVGG
-
 ?
RQYRVVGG + H2O
-
 Homo sapiens RQYR + VVGG
-
 ?
RRARVVGG + H2O
-
 Homo sapiens RRAR + VVGG
-
 ?
RYARVVGG + H2O
-
 Homo sapiens RYAR + VVGG
-
 ?
trask + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
matriptase
-
 Homo sapiens
matriptase-2
-
 Homo sapiens
type II transmembrane serine protease
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.3
-
 RRARVVGG
-
 Homo sapiens
0.3
-
 RQARAVGG
-
 Homo sapiens
0.3
-
 RAARVVGG
-
 Homo sapiens
0.3
-
 RLARVVGG
-
 Homo sapiens
0.5
-
 RQLRVVGG
-
 Homo sapiens
0.6
-
 RYARVVGG
-
 Homo sapiens
0.7
-
 RQYRVVGG
-
 Homo sapiens
0.8
-
 RQARQVGG
-
 Homo sapiens
0.9
-
 RRARVVGG
-
 Homo sapiens
1
-
 matriptase
-
 Homo sapiens
1
-
 RQARVVGG
-
 Homo sapiens
1.5
-
 matriptase
-
 Homo sapiens
1.5
-
 RQARVVGG
-
 Homo sapiens
2
-
 RQARYVGG
-
 Homo sapiens
2.2
-
 protease-activated receptor-2
-
 Homo sapiens
5.5
-
 RQARAVGG
-
 Homo sapiens
6.8
-
 filaggrin
-
 Homo sapiens
7.2
-
 trask
-
 Homo sapiens
7.2
-
 alphaEbeta7 integrin
-
 Homo sapiens
26
-
 RQRRVVGG
-
 Homo sapiens
32
-
 filaggrin
-
 Homo sapiens
45
-
 alphaEbeta7 integrin
-
 Homo sapiens
46
-
 trask
-
 Homo sapiens
61
-
 protease-activated receptor-2
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Homo sapiens
8.5
-
 activity assay Homo sapiens
8.5
-
 acivity assay Homo sapiens