Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.109 extracted from

  • Tseng, I.C.; Chou, F.P.; Su, S.F.; Oberst, M.; Madayiputhiya, N.; Lee, M.S.; Wang, J.K.; Sloane, D.E.; Johnson, M.; Lin, C.Y.
    Purification from human milk of matriptase complexes with secreted serpins: mechanism for inhibition of matriptase other than HAI-1 (2008), Am. J. Physiol. Cell Physiol., 295, C423-C431.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
hepatocyte growth factor activator inhibitor HAI-1, zymogen activator of matriptase Homo sapiens
additional information controlled by a serpin complex, consisting of antithrombin III, alpha1-antitrypsin and alpha2-antiplasmin Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
hepatocyte growth factor activator inhibitor HAI-1, conventional protease inhibitor Homo sapiens
additional information controlled by a serpin complex, consisting of antithrombin III, alpha1-antitrypsin and alpha2-antiplasmin Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25000
-
serine protease domain, identified by SDS-PAGE, Western blot analysis and LC-MS,MS, without serpin complex Homo sapiens
45000
-
noncatalytic domain, identified by SDS-PAGE, Western blot analysis and LC-MS,MS Homo sapiens
80000
-
serine protease domain, identified by SDS-PAGE, Western blot analysis and LC-MS,MS, including serpin complex Homo sapiens
110000
-
matripase complex Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y5Y6
-
-

Purification (Commentary)

Purification (Comment) Organism
from human milk using a CM-Sepharose FF column and a HAI-1 immunoaffinity column Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
Homo sapiens
-
carcinoma cell
-
Homo sapiens
-
epithelial cell
-
Homo sapiens
-
macrophage
-
Homo sapiens
-
mammary epithelial cell line
-
Homo sapiens
-
milk
-
Homo sapiens
-
monocyte
-
Homo sapiens
-
ovary cancer cell line
-
Homo sapiens
-

Subunits

Subunits Comment Organism
heteromer noncatalytic domain 45 kDa, serine protease domain 25 kDa, serpins 55 kDa Homo sapiens

Synonyms

Synonyms Comment Organism
epithin
-
Homo sapiens
matriptase
-
Homo sapiens
MT-SP1
-
Homo sapiens
ST-14
-
Homo sapiens
TADG15
-
Homo sapiens
type 2 transmembrane serine protease
-
Homo sapiens