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Literature summary for 3.4.21.109 extracted from

  • Szabo, R.; Molinolo, A.; List, K.; Bugge, T.H.
    Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development (2007), Oncogene, 26, 1546-1556.
    View publication on PubMed
Search for more literature for 3.4.21.109

Protein Variants

Protein Variants Comment Organism
additional information genetic ablation of the enzyme in hepatocyte growth factor activator inhibitor-1-deficient embryos restores the integrity of chorionic trophoblasts and enables placental labyrinth formation and development in turn, which otherwise is prevented, overview, phenotype of single enzyme knockout and double enzyme and inhibitor knockout mutant embryos, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
hepatocyte growth factor activator inhibitor-1 HAI-1, a Kunitz-type transmembrane serine protease inhibitor, complex formation with the enzyme, enzyme inhibition is essential for placental development, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development, mechanism, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
embryo the enzyme is co-expressed with hepatocyte growth factor activator inhibitor-1 in both extraembryonic and embryonic tissue Mus musculus
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additional information the enzyme is co-expressed with hepatocyte growth factor activator inhibitor-1 in both extraembryonic and embryonic tissue, overview Mus musculus
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placenta enzyme inhibition is essential for placental development, overview Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development, mechanism, overview Mus musculus ?
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 ?