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Literature summary for 3.4.21.109 extracted from

  • Darragh, M.R.; Bhatt, A.S.; Craik, C.S.
    MT-SP1 proteolysis and regulation of cell-microenvironment interactions (2008), Front. Biosci., 13, 528-539.
    View publication on PubMed
Search for more literature for 3.4.21.109

Protein Variants

Protein Variants Comment Organism
additional information null mice show impaired development of the hair follicles and immune system and are unable to survive 48 hours past birth due to rapid dehydration through an abnormally formed epidermal barrier Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
hepatocyte growth factor activator inhibitor-1 is required for proper development of placenta, overview Homo sapiens
hepatocyte growth factor activator inhibitor-1 is required for proper development of placenta, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane MT-SP1 is a type II transmembrane serine protease Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
HGF/SF + H2O Homo sapiens i.e. hepatocyte growth factor/scatter factor, growth factor ?
-
 ?
IGFBP-rP1 + H2O Homo sapiens an adhesion factor ?
-
 ?
additional information Homo sapiens physiological functions, overview, MT-SP1 is a type II transmembrane serine protease implicated in a range of cancers including those of the breast, cervix, ovaries, prostate, colon and gastrointestinal tract, MT-SP1 plays a role in embryologic development ?
-
 ?
additional information Mus musculus physiological functions, overview, MT-SP1 is critical for proper epidermal development and postnatal survival, MT-SP1 plays a role in embryologic development ?
-
 ?
MSP-1 + H2O Homo sapiens i.e. macrophage-stimulating protein 1, a growth factor ?
-
 ?
PAR-2 + H2O Mus musculus G-protein coupled receptor ?
-
 ?
PAR-2 + H2O Homo sapiens G-protein coupled receptor ?
-
 ?
prostasin + H2O Mus musculus a serine protease ?
-
 ?
prostasin + H2O Homo sapiens a serine protease ?
-
 ?
serine protease uPA + H2O Mus musculus
-
 ?
-
 ?
serine protease uPA + H2O Homo sapiens
-
 ?
-
 ?
trask + H2O Homo sapiens a transmembrane glycoprotein ?
-
 ?
VEGFR-2 + H2O Mus musculus i.e. vascular endothelial growth factor receptor 2, a growth factor receptor ?
-
 ?
VEGFR-2 + H2O Homo sapiens i.e. vascular endothelial growth factor receptor 2, a growth factor receptor ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 gene ST14
-
Mus musculus
-
 gene ST14
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification MT-SP1 is activated by cleavage at Arg614 with the catalytic domain remaining attached to the upstream domains via a disulfide bond, the activation cleavage sequence of MT-SP1 is RXQXAXRXXV, MT-SP1 is able to autoactivate both in solution in the membrane-bound form Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
breast
-
 Homo sapiens
-
breast cancer cell
-
 Homo sapiens
-
cervix
-
 Homo sapiens
-
colon
-
 Homo sapiens
-
gastrointestinal tract
-
 Homo sapiens
-
ovary
-
 Homo sapiens
-
prostate
-
 Homo sapiens
-
prostate cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
HGF/SF + H2O i.e. hepatocyte growth factor/scatter factor, growth factor Homo sapiens ?
-
 ?
IGFBP-rP1 + H2O an adhesion factor Homo sapiens ?
-
 ?
additional information substrate specificity, overview Mus musculus ?
-
 ?
additional information substrate specificity, overview Homo sapiens ?
-
 ?
additional information physiological functions, overview, MT-SP1 is a type II transmembrane serine protease implicated in a range of cancers including those of the breast, cervix, ovaries, prostate, colon and gastrointestinal tract, MT-SP1 plays a role in embryologic development Homo sapiens ?
-
 ?
additional information physiological functions, overview, MT-SP1 is critical for proper epidermal development and postnatal survival, MT-SP1 plays a role in embryologic development Mus musculus ?
-
 ?
MSP-1 + H2O i.e. macrophage-stimulating protein 1, a growth factor Homo sapiens ?
-
 ?
PAR-2 + H2O G-protein coupled receptor Mus musculus ?
-
 ?
PAR-2 + H2O G-protein coupled receptor Homo sapiens ?
-
 ?
prostasin + H2O a serine protease Mus musculus ?
-
 ?
prostasin + H2O a serine protease Homo sapiens ?
-
 ?
serine protease uPA + H2O
-
 Mus musculus ?
-
 ?
serine protease uPA + H2O
-
 Homo sapiens ?
-
 ?
trask + H2O a transmembrane glycoprotein Homo sapiens ?
-
 ?
trask + H2O i.e. CDCP1 or SIMA 135, a transmembrane glycoprotein Homo sapiens ?
-
 ?
VEGFR-2 + H2O i.e. vascular endothelial growth factor receptor 2, a growth factor receptor Mus musculus ?
-
 ?
VEGFR-2 + H2O i.e. vascular endothelial growth factor receptor 2, a growth factor receptor Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
epithin
-
 Mus musculus
epithin
-
 Homo sapiens
matriptase
-
 Mus musculus
matriptase
-
 Homo sapiens
MT-SP1
-
 Mus musculus
MT-SP1
-
 Homo sapiens
prostamin
-
 Mus musculus
prostamin
-
 Homo sapiens
PRSS14
-
 Mus musculus
PRSS14
-
 Homo sapiens
SNC19
-
 Mus musculus
SNC19
-
 Homo sapiens
TADG-15
-
 Mus musculus
TADG-15
-
 Homo sapiens