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Literature summary for 3.4.21.109 extracted from
- Matriptase-dependent cell surface proteolysis in epithelial development and pathogenesis (2007), Front. Biosci., 12, 5060-5070.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene ST14, DNA and amino acid sequence determination and anaylsis | Homo sapiens |
| gene ST14, DNA and amino acid sequence determination and anaylsis, co-expression of matriptase with HAI-1 in basal keratinocytes of mouse epidermis negates the effects of matriptase | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| G827R | naturally occurring mutation, the rare congenital human disorder, autosomal recessive ichthyosis with hypotrichosis is linked to homozygosity for a C2672GA mutation located in exon 19 of the ST14 gene, phenotype, overview | Homo sapiens |
| additional information | pathogenesis of dysregulated matriptase activity, dysregulated matriptase potently supports epithelial transformation, overview | Homo sapiens |
| additional information | phenotype of enzyme-deficient mice and pathogenesis of dysregulated matriptase activity, overview, early lethality of ST14 null mice, transgenic mice expressing modest levels of matriptase in basal keratinocytes display progressive epidermal hyperplasia with fibrosis and dermal inflammation, which spontaneously progresses to invasive squamous cell carcinoma | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| hepatocyte growth factor activator inhibitor-1 | HAI-1 | Homo sapiens | |
| hepatocyte growth factor activator inhibitor-1 | HAI-1 | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | - |
Mus musculus | 9986 | - |
| cell surface | - |
Homo sapiens | 9986 | - |
| additional information | enzyme topology, overview | Mus musculus | - |
- |
| additional information | enzyme topology, overview | Homo sapiens | - |
- |
| plasma membrane | matriptase-2 is a type II transmembrane serine protease, the short intracellular domain of matriptase, residues 1-54, interact directly with the actin-associated protein filamin, and likely serves to locate matriptase to microdomains of the plasma membrane | Mus musculus | 5886 | - |
| plasma membrane | matriptase-2 is a type II transmembrane serine protease, the short intracellular domain of matriptase, residues 1-54, interact directly with the actin-associated protein filamin, and likely serves to locate matriptase to microdomains of the plasma membrane | Homo sapiens | 5886 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | reduced matriptase activity is associated with incomplete terminal differentiation of epidermis, epidermal appendages, oral epithelium, and, likely, other epithelial structures, matriptase activity must be tightly controlled in epithelial tissues by transcriptional and posttranslational mechanisms, as matriptase dysregulation can cause embryonic demise as well as malignant transformation | ? | - |
? |  |
| additional information | Mus musculus | reduced matriptase activity is associated with incomplete terminal differentiation of epidermis, epidermal appendages, oral epithelium, and, likely, other epithelial structures, matriptase activity must be tightly controlled in epithelial tissues by transcriptional and posttranslational mechanisms, as matriptase dysregulation can cause embryonic demise as well as malignant transformation, spatial dysregulation of matriptase leads to the activation of the PI3K-Akt signaling pathway, and dysregulated matriptase synergizes strongly with activated ras to promote epithelial carcinogenesis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
gene ST14, i.e. suppression of tumorgenecity14 | - |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal medulla | - |
Homo sapiens | - |
| ameloblast | - |
Mus musculus | - |
| blood | - |
Mus musculus | - |
| blood | - |
Homo sapiens | - |
| breast cancer cell | - |
Homo sapiens | - |
| colon | - |
Mus musculus | - |
| colon | - |
Homo sapiens | - |
| cornea | - |
Mus musculus | - |
| embryo | expression pattern during development, overview | Mus musculus | - |
| embryo | expression pattern during development, overview | Homo sapiens | - |
| epidermis | - |
Mus musculus | - |
| epidermis | - |
Homo sapiens | - |
| epididymis | - |
Mus musculus | - |
| epididymis | - |
Homo sapiens | - |
| epithelial carcinoma cell | - |
Homo sapiens | - |
| epithelial cell | matriptase-dependent cell surface proteolysis in epithelial development and pathogenesis, overview | Mus musculus | - |
| epithelial cell | matriptase-dependent cell surface proteolysis in epithelial development and pathogenesis, overview | Homo sapiens | - |
| epithelium | - |
Mus musculus | - |
| epithelium | - |
Homo sapiens | - |
| epithelium | tracheal, esophageal, gastric, broncheal and alveolar, of scretory duct, intestinal, a dof the urogenityl tract, overview | Mus musculus | - |
| epithelium | tracheal, esophageal, gastric, broncheal and alveolar, of scretory duct, intestinal, a dof the urogenityl tract, overview | Homo sapiens | - |
| esophagus | - |
Mus musculus | - |
| esophagus | - |
Homo sapiens | - |
| gall bladder | - |
Mus musculus | - |
| gall bladder | - |
Homo sapiens | - |
| glandular epithelium | - |
Mus musculus | - |
| glandular epithelium | - |
Homo sapiens | - |
| hair follicle | - |
Homo sapiens | - |
| keratinocyte | - |
Mus musculus | - |
| keratinocyte | - |
Homo sapiens | - |
| kidney | - |
Mus musculus | - |
| kidney | - |
Homo sapiens | - |
| liver | - |
Mus musculus | - |
| lung | - |
Mus musculus | - |
| lung | - |
Homo sapiens | - |
| macrophage | - |
Mus musculus | - |
| macrophage | - |
Homo sapiens | - |
| mammary gland | - |
Mus musculus | - |
| mammary gland | - |
Homo sapiens | - |
| monocyte | - |
Mus musculus | - |
| monocyte | - |
Homo sapiens | - |
| additional information | tissue distribution, overview, postnatal expression pattern, overview | Mus musculus | - |
| additional information | tissue distribution, overview, postnatal expression pattern, overview | Homo sapiens | - |
| oral cavity | keratinocytes in tongue, hard palate, bucca, gingiva, and lip | Mus musculus | - |
| ovary | - |
Homo sapiens | - |
| oviduct | - |
Mus musculus | - |
| oviduct | - |
Homo sapiens | - |
| pancreas | - |
Mus musculus | - |
| pancreas | - |
Homo sapiens | - |
| prostate | - |
Mus musculus | - |
| salivary gland | - |
Mus musculus | - |
| seminal vesicle | - |
Mus musculus | - |
| seminal vesicle | - |
Homo sapiens | - |
| stomach | - |
Mus musculus | - |
| stomach | - |
Homo sapiens | - |
| stratum corneum | - |
Mus musculus | - |
| stratum corneum | - |
Homo sapiens | - |
| stratum granulosum | - |
Mus musculus | - |
| stratum granulosum | - |
Homo sapiens | - |
| thymus | - |
Mus musculus | - |
| thyroid gland | - |
Homo sapiens | - |
| ureter | - |
Mus musculus | - |
| urinary bladder | - |
Mus musculus | - |
| urinary bladder | - |
Homo sapiens | - |
| uterus | - |
Mus musculus | - |
| uterus | - |
Homo sapiens | - |
| vas deferens | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | reduced matriptase activity is associated with incomplete terminal differentiation of epidermis, epidermal appendages, oral epithelium, and, likely, other epithelial structures, matriptase activity must be tightly controlled in epithelial tissues by transcriptional and posttranslational mechanisms, as matriptase dysregulation can cause embryonic demise as well as malignant transformation | Homo sapiens | ? | - |
? | |
| additional information | reduced matriptase activity is associated with incomplete terminal differentiation of epidermis, epidermal appendages, oral epithelium, and, likely, other epithelial structures, matriptase activity must be tightly controlled in epithelial tissues by transcriptional and posttranslational mechanisms, as matriptase dysregulation can cause embryonic demise as well as malignant transformation, spatial dysregulation of matriptase leads to the activation of the PI3K-Akt signaling pathway, and dysregulated matriptase synergizes strongly with activated ras to promote epithelial carcinogenesis | Mus musculus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | domain structure, overview | Mus musculus |
| More | domain structure, overview | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| epithin | - |
Homo sapiens |
| membrane-type serine protease1 | - |
Homo sapiens |
| MT-SP1 | - |
Homo sapiens |
| SNC19 | - |
Homo sapiens |
| TADG-15 | - |
Homo sapiens |
| tumor-associated differentially expressed gene-15 | - |
Homo sapiens |
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