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Literature summary for 3.4.21.109 extracted from

  • Netzel-Arnett, S.; Currie, B.M.; Szabo, R.; Lin, C.Y.; Chen, L.M.; Chai, K.X.; Antalis, T.M.; Bugge, T.H.; List, K.
    Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation (2006), J. Biol. Chem., 281, 32941-32945.
    View publication on PubMed
Search for more literature for 3.4.21.109

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane matriptase is a type II transmembrane trypsin-like serine protease Mus musculus 16020
-
soluble
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus matriptase, a type II transmembrane serine protease, and prostasin, a glycosylphosphatidylinositol-anchored membrane serine protease, are both required for processing of the epidermis-specific polyprotein, profilaggrin, stratum corneum formation, and acquisition of epidermal barrier function, matriptase, an autoactivating protease, acts upstream from prostasin to initiate a zymogen cascade that is essential for epidermal differentiation, overview ?
-
 ?
pro-prostasin + H2O Mus musculus soluble matriptase efficiently converts soluble prostasin zymogen to an active two-chain form, prostasin is exclusively found in the zymogen form in matriptase-deficient epidermis prostasin + propeptide of prostasin
-
 ?
profilaggrin + H2O Mus musculus
-
 filaggrin + propeptide of filaggrin
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification matriptase performs autoactivation Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
epidermis
-
 Mus musculus
-
hair follicle
-
 Mus musculus
-
skin
-
 Mus musculus
-
stratum corneum
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information matriptase, a type II transmembrane serine protease, and prostasin, a glycosylphosphatidylinositol-anchored membrane serine protease, are both required for processing of the epidermis-specific polyprotein, profilaggrin, stratum corneum formation, and acquisition of epidermal barrier function, matriptase, an autoactivating protease, acts upstream from prostasin to initiate a zymogen cascade that is essential for epidermal differentiation, overview Mus musculus ?
-
 ?
additional information matriptase performs autoactivation Mus musculus ?
-
 ?
pro-prostasin + H2O soluble matriptase efficiently converts soluble prostasin zymogen to an active two-chain form, prostasin is exclusively found in the zymogen form in matriptase-deficient epidermis Mus musculus prostasin + propeptide of prostasin
-
 ?
pro-prostasin + H2O cleavage after Arg12 within the amino acid sequence QPR12-ITG Mus musculus prostasin + propeptide of prostasin
-
 ?
profilaggrin + H2O
-
 Mus musculus filaggrin + propeptide of filaggrin
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
 assay at Mus musculus