Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | matriptase is a type II transmembrane trypsin-like serine protease | Mus musculus | 16020 | - |
soluble | - |
Mus musculus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | matriptase, a type II transmembrane serine protease, and prostasin, a glycosylphosphatidylinositol-anchored membrane serine protease, are both required for processing of the epidermis-specific polyprotein, profilaggrin, stratum corneum formation, and acquisition of epidermal barrier function, matriptase, an autoactivating protease, acts upstream from prostasin to initiate a zymogen cascade that is essential for epidermal differentiation, overview | ? | - |
? | |
pro-prostasin + H2O | Mus musculus | soluble matriptase efficiently converts soluble prostasin zymogen to an active two-chain form, prostasin is exclusively found in the zymogen form in matriptase-deficient epidermis | prostasin + propeptide of prostasin | - |
? | |
profilaggrin + H2O | Mus musculus | - |
filaggrin + propeptide of filaggrin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | matriptase performs autoactivation | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epidermis | - |
Mus musculus | - |
hair follicle | - |
Mus musculus | - |
skin | - |
Mus musculus | - |
stratum corneum | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | matriptase, a type II transmembrane serine protease, and prostasin, a glycosylphosphatidylinositol-anchored membrane serine protease, are both required for processing of the epidermis-specific polyprotein, profilaggrin, stratum corneum formation, and acquisition of epidermal barrier function, matriptase, an autoactivating protease, acts upstream from prostasin to initiate a zymogen cascade that is essential for epidermal differentiation, overview | Mus musculus | ? | - |
? | |
additional information | matriptase performs autoactivation | Mus musculus | ? | - |
? | |
pro-prostasin + H2O | soluble matriptase efficiently converts soluble prostasin zymogen to an active two-chain form, prostasin is exclusively found in the zymogen form in matriptase-deficient epidermis | Mus musculus | prostasin + propeptide of prostasin | - |
? | |
pro-prostasin + H2O | cleavage after Arg12 within the amino acid sequence QPR12-ITG | Mus musculus | prostasin + propeptide of prostasin | - |
? | |
profilaggrin + H2O | - |
Mus musculus | filaggrin + propeptide of filaggrin | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
assay at | Mus musculus |