Literature summary for 3.4.21.109 extracted from

Ito, Y.; Akinaga, A.; Yamanaka, K.; Nakagawa, T.; Kondo, A.; Dickson, R.B.; Lin, C.Y.; Miyauchi, A.; Taniguchi, N.; Miyoshi, E.
Co-expression of matriptase and N-acetylglucosaminyltransferase V in thyroid cancer tissues - its possible role in prolonged stability in vivo by aberrant glycosylation (2006), Glycobiology, 16, 368-374.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	prolonged stabilization of matriptase by GnT-V-mediated glycosylation in vivo, thus extending its half-life and permitting it to play role in the early phases of papillary carcinoma, but not in its later phase progression, overview	Homo sapiens

Application

Application	Comment	Organism
medicine	prolonged stabilization of matripase is stabilized by UDP-N-acetylglucosamine: alpha-mannoside beta-1,6-N-acetylglucosminyltransferase-mediated glycosylation in vivo, thus extending its halftime and permitting it to play role in the early phases of papillary carcinoma, but not in its later progression	Homo sapiens

General Stability

General Stability	Organism
prolonged stabilization of matriptase by GnT-V-mediated glycosylation in vivo, thus extending its half-life and permitting it to play role in the early phases of papillary carcinoma, but not in its later phase progression, overview	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	prolonged stabilization of matriptase by GnT-V-mediated glycosylation in vivo, thus extending its half-life and permitting it to play role in the early phases of papillary carcinoma, but not in its later phase progression, overview	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
carcinoma cell	the secretion of matriptase from cancer cells is increased via the action of GnT-V, i.e. UDP-N-acetylglucosamine:alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase, overview	Homo sapiens	-
additional information	not in normal thyroid tissue	Homo sapiens	-
thyroid cancer cell	44.1% of papillary carcinomas, 15.4% of follicular adenomas, none follicular or anaplastic carcinomas	Homo sapiens	-
thyroid cancer cell	co-expression of matriptase and N-acetylglucosaminyltransferase V in thyroid cancer tissues, analysis of expression of GnT-V and matriptase in thyroid neoplasm tissues, papillary carcinoma and follicular carcinoma, overview	Homo sapiens	-

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Release 2023.1 (January 2023)