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Literature summary for 3.4.21.109 extracted from

  • Oberst, M.D.; Chen, L.L.; Kiyomiya, K.; Williams, C.A.; Lee, M.; Johnson, M.D.; Dickson, R.B.; Lin, C.
    HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease (2005), Am. J. Physiol., 289, C462-C470.
    View publication on PubMed
Search for more literature for 3.4.21.109

Activating Compound

Activating Compound Comment Organism Structure
hepatocyte growth factor activator inhibitor-1
-
 Homo sapiens
sphingosine 1-phosphate mediates translocation of the enzyme to cell-cell junctions, sphingosine 1-phosphate-induced matripase activation is enhancend by reduced hepatocyte growth factor activator inhibitor-1 expression Homo sapiens

Application

Application Comment Organism
medicine multiple roles for hepatocyte growth factor activator inhibitor-1 to regulate matripase, including its proper expression, intracellular trafficking, activation and inhibition Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
into vector pcDNA3.1, expressed in BT549 breast cancer cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
D799A matripase mutant altered in the substrate binding pocket, is able to traffic in the absence of hepatocyte growth factor activator inhibitor-1 Homo sapiens
S805A matripase mutant altered in the catalytic triad, is able to traffic in the absence of hepatocyte growth factor activator inhibitor-1 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
hepatocyte growth factor activator inhibitor-1
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
 immunoblotting, latent NH2 terminal processed form matripase Homo sapiens
85000
-
 immunoblotting, full-length hepatocyte growth factor activator inhibitor-1 complexed with the serine protease domain of matripase Homo sapiens
93000
-
 immunoblotting, latent full-length matripase Homo sapiens
120000
-
 immunoblotting, 70000 active matripase plus full-length hepatocyte growth factor activator inhibitor-1 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
184A1N4 cell proportional increases or decreases in matripase and hepatocyte growth factor activator inhibitor-1 Homo sapiens
-