Literature summary for 3.4.21.105 extracted from

Shen, B.; Buguliskis, J.; Lee, T.; David Sibley, L.
Functional analysis of rhomboid proteases during Toxoplasma invasion (2014), mBio, 5, e01795.

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Organism

Organism	UniProt	Comment	Textmining
Toxoplasma gondii	Q695T8	-	-

General Information

General Information	Comment	Organism
physiological function	deletion of isoform ROM4 blocks the shedding of adhesins such as MIC2 (microneme protein 2), causing them to accumulate on the surface of extracellular parasites. Increased surface adhesins lead to nonproductive attachment, altered gliding motility, impaired moving junction formation, and reduced invasion efficiency. ROM4 is the primary protease involved in adhesin processing and host cell invasion. Triple mutants lacking all isoforms ROM1/ROM4/ROM5 are viable and MIC2 is still efficiently removed from the surface of invaded mutant parasites, implying the existence of ROM-independent mechanisms for adhesin removal during invasion	Toxoplasma gondii

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Release 2023.1 (January 2023)