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Literature summary for 3.4.21.105 extracted from
- Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing (2011), J. Invest. Dermatol., 131, 2486-2494.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3,4-dichloroisocoumarin | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thrombomodulin + H2O | Homo sapiens | - |
soluble thrombomodulin + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HaCaT cell | - |
Homo sapiens | - |
| keratinocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thrombomodulin + H2O | - |
Homo sapiens | soluble thrombomodulin + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| RHBDL2 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | rhombopid protease RHBDL2 is upregulated in HaCaT cells stimulated by scratch wounds. RHBDL2 is also upregulated in ex vivo tissue culture of the injured skin (3-5 days after incision) | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | inhibition of RHBDL2 by 3,4-dichloroisocoumarin or short hairpin RNA significantly inhibits wound-induced thrombomodulin ectodomain shedding and wound healing | Homo sapiens |
| physiological function | RHBDL2 is required for wound recovery, cell migration, and proliferation | Homo sapiens |
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