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Literature summary for 3.4.21.105 extracted from

  • Adrain, C.; Strisovsky, K.; Zettl, M.; Hu, L.; Lemberg, M.K.; Freeman, M.
    Mammalian EGF receptor activation by the rhomboid protease RHBDL2 (2011), EMBO Rep., 12, 421-427.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.105

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
epidermal growth factor + H2O Homo sapiens efficient and specific substrate for rhomboid protease RHBDL2 ?
-
 ?
additional information Homo sapiens rhomboid protease RHBDL2 does not cleave transforming growth factor alpha, epiregulin, betacellulin, amphiregulin, heparin binding-epidermal growth factor, vaccinia virus growth factor, transmembrane protein with EGF-like and two follistatin-like domains 2, calnexin, TACE, site-1 protease, neu differentiation factor beta4alpha (Nrg1 isoform), rat glial cell growth factor (Nrg1 isoform), and Nrg4 ?
-
 ?
Spitz protein + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BEAS-2B cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
additional information RHBDL2 expression is low or absent in HEK-293T, SW-480, HCT-116, MB-453 and COS-7 cells Homo sapiens
-
PNT-1A cell
-
 Homo sapiens
-
T-47D cell
-
 Homo sapiens
-
U-1752 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
epidermal growth factor + H2O efficient and specific substrate for rhomboid protease RHBDL2 Homo sapiens ?
-
 ?
additional information rhomboid protease RHBDL2 does not cleave transforming growth factor alpha, epiregulin, betacellulin, amphiregulin, heparin binding-epidermal growth factor, vaccinia virus growth factor, transmembrane protein with EGF-like and two follistatin-like domains 2, calnexin, TACE, site-1 protease, neu differentiation factor beta4alpha (Nrg1 isoform), rat glial cell growth factor (Nrg1 isoform), and Nrg4 Homo sapiens ?
-
 ?
Spitz protein + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
RHBDL2
-
 Homo sapiens
rhomboid protease
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the rhomboid protease RHBDL2 cleaves epidermal growth factor outside its transmembrane domain, thereby facilitating its secretion and triggering activation of the epidermal growth factor receptor. RHBDL2 regulates ADAM-independent epidermal growth factor secretion Homo sapiens