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Literature summary for 3.4.21.105 extracted from
- Two Plasmodium rhomboid proteases preferentially cleave different adhesins implicated in all invasive stages of malaria (2006), PLoS Pathog., 2, 922-932.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of N-terminally HA3-tagged ROMs | Plasmodium falciparum |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Plasmodium falciparum | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| adhesin BAEBL + H2O | Plasmodium falciparum | substrate of ROM1 and ROM4 | ? | - |
? |  |
| adhesin CTRP + H2O | Plasmodium falciparum | substrate of ROM1 and ROM4 | ? | - |
? | |
| adhesin EBA-175 + H2O | Plasmodium falciparum | substrate of ROM1 and ROM4 | ? | - |
? | |
| adhesin JESEBL + H2O | Plasmodium falciparum | substrate of ROM1 and ROM4 | ? | - |
? | |
| adhesin MAEBL + H2O | Plasmodium falciparum | substrate of ROM1 and ROM4 | ? | - |
? | |
| adhesin MTRAP + H2O | Plasmodium falciparum | substrate of ROM1 and ROM4 | ? | - |
? | |
| adhesin PFF0800c + H2O | Plasmodium falciparum | substrate of ROM1 and ROM4 | ? | - |
? | |
| adhesin Rh1 + H2O | Plasmodium falciparum | substrate of ROM1 and ROM4 | ? | - |
? | |
| adhesin Rh24 + H2O | Plasmodium falciparum | substrate of ROM1 and ROM4 | ? | - |
? | |
| adhesin Rh2a + H2O | Plasmodium falciparum | substrate of ROM1 and ROM4 | ? | - |
? | |
| adhesin Rh2b + H2O | Plasmodium falciparum | substrate of ROM1 and ROM4 | ? | - |
? | |
| adhesin TRAP + H2O | Plasmodium falciparum | substrate of ROM1 and ROM4 | ? | - |
? | |
| apical membrane antigen 1 + H2O | Plasmodium falciparum | i.e. AMA1, substrate only of ROM1 | ? | - |
? | |
| additional information | Plasmodium falciparum | the two rhomboid proteases ROM1 and ROM4 preferentially cleave different adhesins implicated in all invasive stages of malaria, invasion of host cells by the malaria pathogen relies on parasite transmembrane adhesins that engage host-cell receptors, adhesins must be released by cleavage before the parasite can enter the cell, overview, swapping transmembrane regions between substrates BAEBL and AMA1 switches the relative preferences of ROMs 1 and 4 for these two substrates, no cleavage of adhesin PTRAMP | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Plasmodium falciparum | - |
ROMs 1, 3, 4, 6, 9, and 10 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | the two rhomboid proteases ROM1 and ROM4 are implicated in all invasive stages of malaria, expression analysis of ROMS in heterologous COS1 cells, four ROMs are expressed in the merozoite stage of the lifecycle, while ROM3 is highly expressed in gametocytes and ROM9 is expressed very weakly, overview | Plasmodium falciparum | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| adhesin BAEBL + H2O | substrate of ROM1 and ROM4 | Plasmodium falciparum | ? | - |
? | |
| adhesin CTRP + H2O | substrate of ROM1 and ROM4 | Plasmodium falciparum | ? | - |
? | |
| adhesin EBA-175 + H2O | substrate of ROM1 and ROM4 | Plasmodium falciparum | ? | - |
? | |
| adhesin JESEBL + H2O | substrate of ROM1 and ROM4 | Plasmodium falciparum | ? | - |
? | |
| adhesin MAEBL + H2O | substrate of ROM1 and ROM4 | Plasmodium falciparum | ? | - |
? | |
| adhesin MTRAP + H2O | substrate of ROM1 and ROM4 | Plasmodium falciparum | ? | - |
? | |
| adhesin PFF0800c + H2O | substrate of ROM1 and ROM4 | Plasmodium falciparum | ? | - |
? | |
| adhesin Rh1 + H2O | substrate of ROM1 and ROM4 | Plasmodium falciparum | ? | - |
? | |
| adhesin Rh24 + H2O | substrate of ROM1 and ROM4 | Plasmodium falciparum | ? | - |
? | |
| adhesin Rh2a + H2O | substrate of ROM1 and ROM4 | Plasmodium falciparum | ? | - |
? | |
| adhesin Rh2b + H2O | substrate of ROM1 and ROM4 | Plasmodium falciparum | ? | - |
? | |
| adhesin TRAP + H2O | substrate of ROM1 and ROM4 | Plasmodium falciparum | ? | - |
? | |
| apical membrane antigen 1 + H2O | i.e. AMA1, substrate only of ROM1 | Plasmodium falciparum | ? | - |
? | |
| additional information | the two rhomboid proteases ROM1 and ROM4 preferentially cleave different adhesins implicated in all invasive stages of malaria, invasion of host cells by the malaria pathogen relies on parasite transmembrane adhesins that engage host-cell receptors, adhesins must be released by cleavage before the parasite can enter the cell, overview, swapping transmembrane regions between substrates BAEBL and AMA1 switches the relative preferences of ROMs 1 and 4 for these two substrates, no cleavage of adhesin PTRAMP | Plasmodium falciparum | ? | - |
? | |
| additional information | ROMs 1 and 4 display distinct substrate specificity, overview | Plasmodium falciparum | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| rhomboid protein 4 | - |
Plasmodium falciparum |
| ROM1 | - |
Plasmodium falciparum |
| ROM4 | - |
Plasmodium falciparum |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Plasmodium falciparum |
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