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Literature summary for 3.4.21.105 extracted from
- Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain (2003), Mol. Cell, 11, 1425-1434.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila sp. (in: flies) | - |
- |
- |
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| adhesion protein from Toxoplasma gondii + H2O | MIC-2, MIC-6 and MIC-12 are efficient substrates | Drosophila sp. (in: flies) | ? | - |
? |  |
| adhesion protein from Toxoplasma gondii + H2O | MIC-2, MIC-6 and MIC-12 are efficient substrates | Homo sapiens | ? | - |
? | |
| additional information | no cleavage of EGFR, Delta, TGN38 or TGFalpha | Drosophila sp. (in: flies) | ? | - |
? | |
| Spitz + H2O | site-specific cleavage, the substrate Spitz is recognized by a small region of the Spitz transmembrane domain. This substrate motif is necessary and sufficient for cleavage | Drosophila sp. (in: flies) | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| RHDBL-2 | - |
Homo sapiens |
| rhomboid-1 | - |
Drosophila sp. (in: flies) |
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