Literature summary for 3.4.21.105 extracted from

Herlan, M.; Vogel, F.; Bornhovd, C.; Neupert, W.; Reichert, A.S.
Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA (2003), J. Biol. Chem., 278, 27781-27788.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Saccharomyces cerevisiae	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
l-Mgm1 + H2O	Saccharomyces cerevisiae	rhomboid-type protease Pcp1 is essential for wild type mitochondrial morphology. The processing of the large isoform l-Mgm1 by rhomboid-type protease Pcp1 to s-Mgm1, and the presence of both isoforms of Mgm1 appears to be crucial for wild-type mitochondrial morphology and maintenance of mitochondrial DNA	s-Mgm1 + N-terminal putative transmembrane segment	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
l-Mgm1 + H2O	rhomboid-type protease Pcp1 is essential for wild type mitochondrial morphology. The processing of the large isoform l-Mgm1 by rhomboid-type protease Pcp1 to s-Mgm1, and the presence of both isoforms of Mgm1 appears to be crucial for wild-type mitochondrial morphology and maintenance of mitochondrial DNA	Saccharomyces cerevisiae	s-Mgm1 + N-terminal putative transmembrane segment	-	?
l-Mgm1 + H2O	l-Mgm1 is the large isoform of Mgm1	Saccharomyces cerevisiae	s-Mgm1 + N-terminal putative transmembrane segment	s-Mgm1 is the small isoform of Mgm1	?

Synonyms

Synonyms	Comment	Organism
Pcp1	-	Saccharomyces cerevisiae
rhomboid-type protease Pcp1	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)