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Literature summary for 3.4.21.10 extracted from

  • Liu, X.; Dong, G.; Zhang, J.; Qi, J.; Zheng, C.; Zhou, Y.; Zhu, J.; Sheng, C.; Lue, J.
    Discovery of novel human acrosin inhibitors by virtual screening (2011), J. Comput. Aided Mol. Des., 25, 977-985.
    View publication on PubMed
Search for more literature for 3.4.21.10

Inhibitors

Inhibitors Comment Organism Structure
3-(4-nitrophenyl)-1,2-oxazole-5-carbaldehyde
-
 Homo sapiens
3-[4-([[4-(aminomethyl)cyclohexyl]carbonyl]oxy)phenyl]propanoic acid
-
 Homo sapiens
4-(acetylamino)phenyl 4-carbamimidamidobenzoate
-
 Homo sapiens
4-aminobenzamidine
-
 Homo sapiens
4-[(2-methylbenzyl)(methylsulfonyl)amino]-N-(pyridin-4-ylmethyl)benzamide
-
 Homo sapiens
5-(2,4-dichlorophenyl)-1,2-oxazole-3-carbaldehyde
-
 Homo sapiens
DV-1006
-
 Homo sapiens
methyl 4-methyl-3-([4-[(2-methylbenzyl)(methylsulfonyl)amino]benzoyl]amino)benzoate
-
 Homo sapiens
N,N-dibenzyl-2-[4-(propan-2-ylsulfamoyl)phenoxy]acetamide
-
 Homo sapiens
N-(4-chlorophenyl)-N-[2-[(2E)-2-(3-methoxy-4-methylbenzylidene)hydrazinyl]-2-oxoethyl]benzenesulfonamide (non-preferred name)
-
 Homo sapiens
N-alpha-tosyl-L-lysyl-chloromethylketone
-
 Homo sapiens
N-cyclohexyl-2-[(4,6-diphenylpyrimidin-2-yl)sulfanyl]acetamide
-
 Homo sapiens
N-[4-(dipropylsulfamoyl)phenyl]-3,4-diethoxybenzamide
-
 Homo sapiens
N-[4-[(4-benzylpiperazin-1-yl)carbonyl]phenyl]-2,3,5,6-tetramethylbenzenesulfonamide
-
 Homo sapiens
N-[4-[(4-benzylpiperazin-1-yl)carbonyl]phenyl]-4-tert-butylbenzenesulfonamide
-
 Homo sapiens
N-[4-[(4-fluorophenyl)sulfamoyl]phenyl]-3,4,5-trimethoxybenzamide
-
 Homo sapiens
N-[4-[(4-methoxyphenyl)sulfamoyl]phenyl]-2-(naphthalen-1-yloxy)acetamide
-
 Homo sapiens
suramin
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epididymis
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-alpha-benzoyl-L-arginine-4-nitroanilide + H2O
-
 Homo sapiens N-alpha-benzoyl-L-arginine + 4-nitroaniline
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0033
-
 in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37°C Homo sapiens 3-[4-([[4-(aminomethyl)cyclohexyl]carbonyl]oxy)phenyl]propanoic acid
0.008
-
 in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37°C Homo sapiens 4-(acetylamino)phenyl 4-carbamimidamidobenzoate
0.014
-
 in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37°C Homo sapiens N-(4-chlorophenyl)-N-[2-[(2E)-2-(3-methoxy-4-methylbenzylidene)hydrazinyl]-2-oxoethyl]benzenesulfonamide (non-preferred name)
0.1426
-
 in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37°C Homo sapiens N-alpha-tosyl-L-lysyl-chloromethylketone
0.1555
-
 in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37°C Homo sapiens methyl 4-methyl-3-([4-[(2-methylbenzyl)(methylsulfonyl)amino]benzoyl]amino)benzoate
0.2053
-
 in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37°C Homo sapiens N-[4-[(4-fluorophenyl)sulfamoyl]phenyl]-3,4,5-trimethoxybenzamide
0.3018
-
 in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37°C Homo sapiens N-[4-(dipropylsulfamoyl)phenyl]-3,4-diethoxybenzamide
0.3447
-
 in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37°C Homo sapiens 4-[(2-methylbenzyl)(methylsulfonyl)amino]-N-(pyridin-4-ylmethyl)benzamide
0.3551
-
 in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37°C Homo sapiens N-cyclohexyl-2-[(4,6-diphenylpyrimidin-2-yl)sulfanyl]acetamide
0.39
-
 in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37°C Homo sapiens 5-(2,4-dichlorophenyl)-1,2-oxazole-3-carbaldehyde
0.42
-
 in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37°C Homo sapiens 3-(4-nitrophenyl)-1,2-oxazole-5-carbaldehyde
0.4267
-
 in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37°C Homo sapiens N,N-dibenzyl-2-[4-(propan-2-ylsulfamoyl)phenoxy]acetamide
0.6248
-
 in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37°C Homo sapiens N-[4-[(4-benzylpiperazin-1-yl)carbonyl]phenyl]-2,3,5,6-tetramethylbenzenesulfonamide
0.6678
-
 in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37°C Homo sapiens N-[4-[(4-methoxyphenyl)sulfamoyl]phenyl]-2-(naphthalen-1-yloxy)acetamide
3.057
-
 in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37°C Homo sapiens N-[4-[(4-benzylpiperazin-1-yl)carbonyl]phenyl]-4-tert-butylbenzenesulfonamide