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Literature summary for 3.4.21.10 extracted from

  • Jiang, J.; Liu, X.; Zhen, C.; Zhou, Y.; Zhu, J.; Lv, J.; Sheng, C.
    Acrosin structure-based design, synthesis and biological activities of 7-azaindol derivatives as new acrosin inhibitors (2011), Chin. Chem. Lett., 22, 272-275.
No PubMed abstract available
Search for more literature for 3.4.21.10

Inhibitors

Inhibitors Comment Organism Structure
ethyl 1-(phenylcarbonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
 Homo sapiens
ethyl 1-(thiophen-2-ylcarbonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
 Homo sapiens
ethyl 1-[(2,4-dichlorophenyl)acetyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
 Homo sapiens
ethyl 1-[(2,4-dichlorophenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
 Homo sapiens
ethyl 1-[(2,4-dimethoxyphenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
 Homo sapiens
ethyl 1-[(2,6-dichlorophenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
 Homo sapiens
ethyl 1-[(2-bromo-4-fluorophenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
 Homo sapiens
ethyl 1-[(2-chloro-4-fluorophenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate most potent inhibitor Homo sapiens
ethyl 1-[(2-chlorophenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
 Homo sapiens
ethyl 1-[(2-fluorophenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
 Homo sapiens
ethyl 1-[(2-methoxyphenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
 Homo sapiens
ethyl 1-[(2-methylphenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
 Homo sapiens
ethyl 1-[(3,4-dichlorophenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
 Homo sapiens
ethyl 1-[(3-fluorophenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
 Homo sapiens
N-tosyl-L-lysine chloromethylketone
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00029
-
 pH and temperature not specified in the publication Homo sapiens ethyl 1-[(2,4-dichlorophenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
0.00174
-
 pH and temperature not specified in the publication Homo sapiens ethyl 1-[(2-bromo-4-fluorophenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
0.00221
-
 pH and temperature not specified in the publication Homo sapiens ethyl 1-(phenylcarbonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
0.00347
-
 pH and temperature not specified in the publication Homo sapiens ethyl 1-[(2-chloro-4-fluorophenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
0.1426
-
 pH and temperature not specified in the publication Homo sapiens N-tosyl-L-lysine chloromethylketone