Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.10 extracted from

  • Gupta, G.; Jain, R.K.; Maikhuri, J.P.; Shukla, P.K.; Kumar, M.; Roy, A.K.; Patra, A.; Singh, V.; Batra, S.
    Discovery of substituted isoxazolecarbaldehydes as potent spermicides, acrosin inhibitors and mild anti-fungal agents (2005), Hum. Reprod., 20, 2301-2308.
    View publication on PubMed
Search for more literature for 3.4.21.10

Inhibitors

Inhibitors Comment Organism Structure
3-(2,4-dichlorophenyl)isoxazole-5-carbaldehyde 50% inhibition at 5.8 mM, weak antifungal activity against Candida albicans Homo sapiens
3-(2-bromophenyl)isoxazole-5-carbaldehyde 50% inhibition at 1.25 mM, weak antifungal activity against Candida albicans Homo sapiens
3-(2-chlorophenyl)isoxazole-5-carbaldehyde 50% inhibition at 1.1 mM, weak antifungal activity against Candida albicans Homo sapiens
3-(3-bromophenyl)isoxazole-5-carbaldehyde 50% inhibition at 4.8 mM, weak antifungal activity against Candida albicans Homo sapiens
3-(3-chlorophenyl)isoxazole-5-carbaldehyde 50% inhibition at 0.625 mM, weak antifungal activity against Candida albicans Homo sapiens
3-(4-chlorophenyl)isoxazole-5-carbaldehyde 50% inhibition at 1.8 mM, weak antifungal activity against Candida albicans Homo sapiens
3-(4-fluorophenyl)isoxazole-5-carbaldehyde 50% inhibition at 4.0 mM, weak antifungal activity against Candida albicans Homo sapiens
3-(4-nitrophenyl)isoxazole-5-carbaldehyde 50% inhibition at 0.42 mM, weak antifungal activity against Candida albicans Homo sapiens
5-(2,4-dichlorophenyl)isoxazole-3-carbaldehyde 50% inhibition at 0.39 mM, weak antifungal activity against Candida albicans Homo sapiens
5-(2-chlorophenyl)isoxazole-3-carbaldehyde 50% inhibition at 1.0 mM, weak antifungal activity against Candida albicans Homo sapiens
5-(3-bromophenyl)isoxazole-3-carbaldehyde 50% inhibition at 1.1 mM, weak antifungal activity against Candida albicans Homo sapiens
5-(4-methylphenyl)isoxazole-3-carbaldehyde 50% inhibition at 2.4 mM, weak antifungal activity against Candida albicans Homo sapiens
5-phenylisoxazole-3-carbaldehyde 50% inhibition at 2.4 mM, weak antifungal activity against Candida albicans Homo sapiens
Benzamidine hydrochloride 50% inhibition at 2.2 mM, weak antifungal activity against Candida albicans Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
semen
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Nalpha-benzoyl-DL-arginine-p-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.28
-
 3-(4-nitrophenyl)isoxazole-5-carbaldehyde pH 8.0, 37°C Homo sapiens