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Literature summary for 3.4.21.1 extracted from

  • Chen, Q.; Zhang, J.; Zhao, K.; Li, W.; Miao, Q.; Sun, Y.; Zhao, X.; Wei, T.; Yang, F.
    Lysosomal chymotrypsin induces mitochondrial fission in apoptotic cells by proteolytic activation of calcineurin (2014), Protein Cell, 5, 643-647.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.1

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol upon LeuLeuOMe treatment, which induces lysosomal membrane permeabilization, lysosomal chymotrypsin is relocated to the cytosol Homo sapiens 5829
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lysosome chymotrypsin colocalizes with the lysosomal marker protein LAMP1 Homo sapiens 5764
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Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
calcineurin + H2O
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 Homo sapiens ? chymotrypsin cleaves calcineurin into a 47-kDa fragment and a 13-kDa fragment, the cleavage activates the phosphatase activity of calcineurin in a Ca2+/CaM-independent manner ?

General Information

General Information Comment Organism
physiological function intracellular delivery of chymotrypsin significantly potentiates apoptosis, and chymotrypsin is involved in mitochondrial fission during apoptosis. Chymotrypsin cleaves calcineurin into a 47-kDa fragment and a 13-kDa fragment, the cleavage activates the phosphatase activity of calcineurin in a Ca2+/CaM-independent manner. Cleaved calcineurin induces the translocation of cytosolic Drp1 to the mitochondria and triggers significant mitochondrial fission Homo sapiens