Literature summary for 3.4.19.12 extracted from

Kabuta, T.; Mitsui, T.; Takahashi, M.; Fujiwara, Y.; Kabuta, C.; Konya, C.; Tsuchiya, Y.; Hatanaka, Y.; Uchida, K.; Hohjoh, H.; Wada, K.
Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity (2013), J. Biol. Chem., 288, 12615-12626.

Search for more literature for 3.4.19.12

Protein Variants

Protein Variants	Comment	Organism
C90S	mutant shows same interaction pattern as wild-type. Mutant shows no hydrolase activity	Homo sapiens
D176A	mutant shows an increased interaction with CDK4 compared to wild-type	Homo sapiens
DELTA148-190	deletion mutant containing amino acids 148-190 interacts with CDK4	Homo sapiens
DELTA148-223	deletion mutant containing amino acids 148-223 interacts with CDK4	Homo sapiens
DELTA160-190	deletion mutant containing amino acids 160-190 interacts with CDK4	Homo sapiens
DELTA160-223	deletion mutant containing amino acids 160-223 interacts with CDK4	Homo sapiens
DELTA188-223	deletion mutant containing amino acids 188-223 does not interact with CDK4	Homo sapiens
E174A	mutant shows an increased interaction with CDK4 compared to wild-type	Homo sapiens
H165A	mutant shows an increased interaction with CDK4 compared to wild-type	Homo sapiens
I93M	mutant shows a stronger interaction with CDK1, CDK4 and CDK5 compared to wild-type. Hydrolase and ligase activity are reduced in mutant compared to wild-type	Homo sapiens
R63A	mutant shows an increased interaction with CDK4 compared to wild-type	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09936	-	-

Synonyms

Synonyms	Comment	Organism
UCH-L1	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	gain- and loss of-function studies reveals that UCH-L1 enhances proliferation of multiple cell types	Homo sapiens
malfunction	RNA interference of UCH-L1 reduces the growth of human xenograft tumors in mice	Homo sapiens
physiological function	UCH-L1 physically interacts with CDK1, CDK4, and CDK5, enhancing their kinase activity	Homo sapiens

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Release 2023.1 (January 2023)