Literature summary for 3.4.19.12 extracted from

Davies, C.W.; Chaney, J.; Korbel, G.; Ringe, D.; Petsko, G.A.; Ploegh, H.; Das, C.
The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK) (2012), Bioorg. Med. Chem. Lett., 22, 3900-3904.

Search for more literature for 3.4.19.12

Crystallization (Commentary)

Crystallization (Comment)	Organism
X-ray structure of UCHL1 co-crystallized with a peptide-based fluoromethylketone inhibitor, benzyloxycarbonyl-Val-Ala-Glu(gamma-methoxy) fluoromethylketone (Z-VAE(OMe)-FMK (VAEFMK)), at 2.35 A resolution is reported	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
benzyloxycarbonyl-Val-Ala-Glu(gamma-methoxy) fluoromethylketone	co-crystal structure reveals that the inhibitor binds in the active-site cleft, irreversibly modifying the active-site cysteine	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09936	-	-

Synonyms

Synonyms	Comment	Organism
UCHL1	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)