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Literature summary for 3.4.19.12 extracted from

  • Seliger, B.; Handke, D.; Schabel, E.; Bukur, J.; Lichtenfels, R.; Dammann, R.
    Epigenetic control of the ubiquitin carboxyl terminal hydrolase 1 in renal cell carcinoma (2009), J. Transl. Med., 7, 90.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
determination of the UCHL1 promoter DNA methylation status and the mechanisms for the heterogeneous UCHL1 expression pattern in renal epithelium and in renal cell carcinoma, overview. Semi-quantitative and real-time RT-PCR analysis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium
-
Homo sapiens
-
kidney epithelium Homo sapiens
-
kidney cancer cell different cell lines Homo sapiens
-

Synonyms

Synonyms Comment Organism
ubiquitin carboxyl terminal hydrolase 1
-
Homo sapiens
ubiquitin carboxyl-terminal hydrolase 1
-
Homo sapiens
UCHL1
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens promoter hypermethylation represents a mechanism for the silencing of the UCHL1 gene expression in in renal carcinoma cells as a concept of an epigenetic control for the expression of UCHL1 during disease progression. Restoration of UCHL1 expression in renal carcinoma cells by treatment with DAC, overview down
Homo sapiens 2'-deoxy-5-azacytidine, DAC, induces UCHL1 expression in renal carcinoma cell lines linked to the demethylation degree of the UCHL1 promoter DNA. Restoration of UCHL1 expression in renal carcinoma cells by treatment with DAC, overview up

General Information

General Information Comment Organism
malfunction UCHL1 overexpression is associated with tumor progression and an altered von Hippel Lindau gene expression in renal cell carcinoma Homo sapiens