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Literature summary for 3.4.19.12 extracted from

  • Papa, L.; Akinyi, L.; Liu, M.C.; Pineda, J.A.; Tepas, J.J.; Oli, M.W.; Zheng, W.; Robinson, G.; Robicsek, S.A.; Gabrielli, A.; Heaton, S.C.; Hannay, H.J.; Demery, J.A.; Brophy, G.M.; Layon, J.; Robertson, C.S.; Hayes, R.L.; Wang, K.K.
    Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury (2010), Crit. Care Med., 38, 138-144.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
diagnostics ubiquitin C-terminal hydrolase is a biomarker in humans for severe traumatic brain injury Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
brain UCH-L1 forms 1-5% of total brain protein Homo sapiens
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cerebrospinal fluid UCH-L1 levels are specifically increased in cerebrospinal fluid in case of traumatic brain damage, quantitative determination in different samples, overview Homo sapiens
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additional information UCH-L1 is enriched in the central nervous system Homo sapiens
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neuron UCH-L1 is present in almost all neurons Homo sapiens
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Synonyms

Synonyms Comment Organism
ubiquitin C-terminal hydrolase
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 Homo sapiens
UCH-L1
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 Homo sapiens

General Information

General Information Comment Organism
malfunction UCH-L1 levels are increased in cerebrospinal fluid in case of traumatic brain damage correlated with a negative survival prognosis, overview Homo sapiens