Literature summary for 3.4.19.12 extracted from

Li, L.; Tao, Q.; Jin, H.; van Hasselt, A.; Poon, F.F.; Wang, X.; Zeng, M.S.; Jia, W.H.; Zeng, Y.X.; Chan, A.T.; Cao, Y.
The tumor suppressor UCHL1 forms a complex with p53/MDM2/ARF to promote p53 signaling and is frequently silenced in nasopharyngeal carcinoma (2010), Clin. Cancer Res., 16, 2949-2958.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuroendocrine cell	UCHL1 is neuroendocrine cell-specific. Neuroendocrine gene expression in the large and small airway epithelium, UCHL1 is overexpressed in over 50% of lung cancers, overview	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
ubiquitin carboxyl-terminal hydrolase L1	-	Homo sapiens
UCHL1	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	UCHL1 is consistently up-regulated in smokers compared with nonsmokers	up

General Information

General Information	Comment	Organism
malfunction	UCHL1 is overexpressed in over 50% of lung cancers, its overexpression in chronic smokers may represent an early event in the complex transformation from normal epithelium to overt malignancy	Homo sapiens
metabolism	ubiquitin carboxyl-terminal hydrolase L1 is a member of the ubiquitin proteasome pathway	Homo sapiens
physiological function	UCHL1 is involved in the degradation of unwanted, misfolded, or damaged proteins within the cell	Homo sapiens

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Release 2023.1 (January 2023)