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Literature summary for 3.4.19.12 extracted from

  • Kim, H.J.; Kim, Y.M.; Lim, S.; Nam, Y.K.; Jeong, J.; Kim, H.J.; Lee, K.J.
    Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis (2009), Oncogene, 28, 117-127.
    View publication on PubMed
Search for more literature for 3.4.19.12

Inhibitors

Inhibitors Comment Organism Structure
RNAi suppressing UCH-L1 expression by RNAi significantly suppresses the invasion in vitro and in vivo, and the activation of Akt and downstream mitogen activates protein kinases c-Jun N-terminal kinases and p38, but not ERK Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens UCH-L1 is a key molecule to regulate tumor-cell invasion by upstream activation of Akt. Expression of UCH-L1 in tumor cells enhances their invasive potential in vitro and in vivo. UCH-L1 changes cell morphology by regulating cell adhesion through Akt-mediated pathway ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens P09936
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Source Tissue

Source Tissue Comment Organism Textmining
additional information UCH-L1 is highly expressed in H157 cells, having high invasive potential. In Akt-negative mutants, overexpression of UCH-L1 does not affect the invasion and migration capability of H157 cells Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information UCH-L1 is a key molecule to regulate tumor-cell invasion by upstream activation of Akt. Expression of UCH-L1 in tumor cells enhances their invasive potential in vitro and in vivo. UCH-L1 changes cell morphology by regulating cell adhesion through Akt-mediated pathway Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
ubiquitin C-terminal hydrolase-L1
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 Homo sapiens
UCH-L1
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 Homo sapiens