Application | Comment | Organism |
---|---|---|
medicine | mono-ubiquitin and ubiquitin dimers may regulate the enzymatic functions of UCH-L1 in vivo | Mus musculus |
Cloned (Comment) | Organism |
---|---|
FLAG-HA tagged UCH-3 expressed in HeLa cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C95A | enhances the interaction of ubiquitin dimers with UCH-L3 | Homo sapiens |
C95S | active site mutant of UCH-L1 | Homo sapiens |
C95S | active site mutant of UCH-L3, enhances the interaction of ubiquitin dimers with UCH-L3 | Homo sapiens |
C95S | retains the affinity to interact with ubiquitin dimers | Mus musculus |
D33A | loses the affinity to interact with ubiquitin dimers. D33A mutant expressing cells do not show any signs of free ubiquitin dimers accumulation | Mus musculus |
D33A | ubiquitin affinity deficient mutant, diminishes the interaction of ubiquitin dimers with UCH-L3 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | in vitro, K48-linked ubiquitin dimers pronouncedly inhibit the hydrolase activity of UCH-L3; mono-ubiquitin, a previously identified interacting protein, inhibits the hydrolase activity of UCH-L1 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | mono-ubiquitin and ubiquitin dimers may regulate the enzymatic function of UCH-L1 in vivo | ? | - |
? | |
additional information | Homo sapiens | mono-ubiquitin and ubiquitin dimers may regulate the enzymatic function of UCH-L3 in vivo | ? | - |
? | |
additional information | Mus musculus | mono-ubiquitin and ubiquitin dimers may regulate the enzymatic functions of UCH-L3, in vivo | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09936 | - |
- |
Homo sapiens | P15374 | - |
- |
Mus musculus | Q9JKB1 | - |
- |
Mus musculus | Q9R0P9 | - |
- |
Purification (Comment) | Organism |
---|---|
affinity purified | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
MEF cell | - |
Mus musculus | - |
additional information | 3T3 cell | Mus musculus | - |
testis | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | mono-ubiquitin and ubiquitin dimers may regulate the enzymatic function of UCH-L1 in vivo | Homo sapiens | ? | - |
? | |
additional information | mono-ubiquitin and ubiquitin dimers may regulate the enzymatic function of UCH-L3 in vivo | Homo sapiens | ? | - |
? | |
additional information | mono-ubiquitin and ubiquitin dimers may regulate the enzymatic functions of UCH-L3, in vivo | Mus musculus | ? | - |
? | |
additional information | UCH-L3 does not function to hydrolyze free ubiquitin dimers | Mus musculus | ? | - |
? | |
additional information | UCH-L3 does not show hydrolase activity toward the K48-linked, K63-linked or linear ubiquitin dimer | Homo sapiens | ? | - |
? | |
ubiquitin-AMC + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ubiquitin carboxy terminal hydrolase-L1 | - |
Homo sapiens |
ubiquitin carboxy terminal hydrolase-L1 | - |
Mus musculus |
ubiquitin carboxy terminal hydrolase-L3 | - |
Homo sapiens |
ubiquitin carboxy terminal hydrolase-L3 | - |
Mus musculus |
UCH-L1 | - |
Homo sapiens |
UCH-L1 | - |
Mus musculus |
UCH-L3 | - |
Homo sapiens |
UCH-L3 | - |
Mus musculus |