Cloned (Comment) | Organism |
---|---|
expression of a catalytically active UCH-L1 in a UCH-L1 negative EBV transformed lymphoblastoid cell line | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | a catalytic mutant has no effect on proliferation of a UCH-L1 negative EBV transformed lymphoblastoid cell line and on inhibiting cell adhesion | Homo sapiens |
additional information | knockdown of UCH-L1 by RNAi inhibits the proliferation of Burkitt's lymphoma cells in suspension and semisolid agar and activates strong LFA-1-dependent homotypic adhesion. Recombinant expression of a catalytically active UCH-L1 promotes the proliferation of a UCH-L1-negative EBV transformed lymphoblastoid cell line, LCL, and inhibited cell adhesion, whereas a catalytic mutant has no effect | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
RNAi | knockdown of UCH-L1, inhibits the proliferation of BL cells in suspension and semisolid agar and activates strong LFA-1 dependent homotypic adhesion | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | UCH-L1 is a player in the signaling pathways that promote the proliferation and invasive capacity of malignant B-cells | ? | - |
? | |
additional information | Homo sapiens | UCH-L1 is a deubiquitinating enzyme that catalyses the hydrolysis of polyubiquitin precursors and small ubiquitin adducts | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P09936 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | - |
Homo sapiens | - |
Burkitt lymphoma cell | UCH-L1 is highly expressed | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | UCH-L1 is a player in the signaling pathways that promote the proliferation and invasive capacity of malignant B-cells | Homo sapiens | ? | - |
? | |
additional information | UCH-L1 is a deubiquitinating enzyme that catalyses the hydrolysis of polyubiquitin precursors and small ubiquitin adducts | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ubiquitin C-terminal hydrolase-L1 | - |
Homo sapiens |
UCH-L1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | UCH-L1 is highly expressed in Burkitt's lymphoma and is up-regulated upon infection of B lymphocytes with Epstein-Barr virus, EBV. Selective up-regulation of the ubiquitin C-terminal hydrolase UCH-L1 in a variety of metastatic tumours contributes to the malignant phenotype | Homo sapiens |
physiological function | UCH-L1 is a player in the signalling pathways that promote the proliferation and invasive capacity of malignant B cells | Homo sapiens |