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Literature summary for 3.4.19.12 extracted from

  • Rolen, U.; Freda, E.; Xie, J.; Pfirmann, T.; Frisan, T.; Masucci, M.G.
    The Ubiquitin C-terminal Hydrolase UCH-L1 regulates B-cell proliferation and integrin activation (2009), J. Cell. Mol. Med., 13, 1666-1678.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression of a catalytically active UCH-L1 in a UCH-L1 negative EBV transformed lymphoblastoid cell line Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information a catalytic mutant has no effect on proliferation of a UCH-L1 negative EBV transformed lymphoblastoid cell line and on inhibiting cell adhesion Homo sapiens
additional information knockdown of UCH-L1 by RNAi inhibits the proliferation of Burkitt's lymphoma cells in suspension and semisolid agar and activates strong LFA-1-dependent homotypic adhesion. Recombinant expression of a catalytically active UCH-L1 promotes the proliferation of a UCH-L1-negative EBV transformed lymphoblastoid cell line, LCL, and inhibited cell adhesion, whereas a catalytic mutant has no effect Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
RNAi knockdown of UCH-L1, inhibits the proliferation of BL cells in suspension and semisolid agar and activates strong LFA-1 dependent homotypic adhesion Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens UCH-L1 is a player in the signaling pathways that promote the proliferation and invasive capacity of malignant B-cells ?
-
?
additional information Homo sapiens UCH-L1 is a deubiquitinating enzyme that catalyses the hydrolysis of polyubiquitin precursors and small ubiquitin adducts ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P09936
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
-
Homo sapiens
-
Burkitt lymphoma cell UCH-L1 is highly expressed Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information UCH-L1 is a player in the signaling pathways that promote the proliferation and invasive capacity of malignant B-cells Homo sapiens ?
-
?
additional information UCH-L1 is a deubiquitinating enzyme that catalyses the hydrolysis of polyubiquitin precursors and small ubiquitin adducts Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
ubiquitin C-terminal hydrolase-L1
-
Homo sapiens
UCH-L1
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Homo sapiens

General Information

General Information Comment Organism
malfunction UCH-L1 is highly expressed in Burkitt's lymphoma and is up-regulated upon infection of B lymphocytes with Epstein-Barr virus, EBV. Selective up-regulation of the ubiquitin C-terminal hydrolase UCH-L1 in a variety of metastatic tumours contributes to the malignant phenotype Homo sapiens
physiological function UCH-L1 is a player in the signalling pathways that promote the proliferation and invasive capacity of malignant B cells Homo sapiens