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Literature summary for 3.4.19.12 extracted from

  • Sakurai, M.; Sekiguchi, M.; Zushida, K.; Yamada, K.; Nagamine, S.; Kabuta, T.; Wada, K.
    Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene (2008), Eur. J. Neurosci., 27, 691-701.
    View publication on PubMed
Search for more literature for 3.4.19.12

Application

Application Comment Organism
medicine UCH-L1 is required for maintenance of memory in a passive avoidance test, exploratory behaviour in a novel environment, and a transcription-dependent component of theta-burst stimulation-induced long-term potentiation in area CA1 of the hippocampus Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information in gracile axonal dystrophy mice with a spontaneous deletion in the Uch-l1 gene, memory in passive avoidance learning, exploratory behaviour and hippocampal CA1 long-term potentiation are reduced, whereas cyclic AMP response element binding protein phosphorylation is altered Mus musculus
additional information UCHL1-deficient gracile axonal dystrophy, i.e. gad, mice are spontaneous mutants with an in-frame deletion in exons 7 and 8 of Uch-l1. Deletion of the gene encoding UCH-L1 leads to a reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Mus musculus
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 C57BL/6J mice
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Mus musculus C57/BL6J
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 C57BL/6J mice
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Mus musculus
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brain neuron-specific expression of UCH-L1 Mus musculus
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cornu ammonis area 1 Mus musculus
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hippocampus
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 Mus musculus
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additional information UCH-L1 is exclusively expressed in brain and testis Mus musculus
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pyramidal neuron
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 Mus musculus
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testis
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 Mus musculus
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Synonyms

Synonyms Comment Organism
ubiquitin C-terminal hydrolase L1
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 Mus musculus
UCH-L1
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 Mus musculus

General Information

General Information Comment Organism
physiological function UCH-L1 mediates maintenance of the temporal integrity and persistence of cyclic AMP response element binding protein, CREB, phosphorylation in the brain Mus musculus