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Literature summary for 3.4.19.12 extracted from
- Mechanistic studies of ubiquitin C-terminal hydrolase L1 (2006), Biochemistry, 45, 2443-2452.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ubiquitin | - |
Homo sapiens |  |
| Ubiquitin aldehyde | inhibition mechanism | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinectis | Homo sapiens | |
| 0.000035 | - |
ubiquitinyl-7-amido-4-methylcoumarin | pH 7.5, 25°C | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | UCH-L1 is involved in Parkinson's disease | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Homo sapiens | P09936 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | UCH-L1 is involved in Parkinson's disease | Homo sapiens | ? | - |
? | |
| ubiquitin-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | ubiquitin + 7-amino-4-methylcoumarin | - |
ir | |
| ubiquitin-alcohol + H2O | - |
Homo sapiens | ubiquitin + alcohol | - |
ir | |
| ubiquitinyl-7-amido-4-methylcoumarin + H2O | mechanistic studies | Homo sapiens | ubiquitin + 7-amino-4-methylcoumarin | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | the enzyme belongs to the family of ubiquitin-specific processing enzymes | Homo sapiens |
| ubiquitin C-terminal hydrolase L1 | - |
Homo sapiens |
| UCH-L1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
analysis of temperature dependence of the reaction, overview | Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.001 | - |
ubiquitinyl-7-amido-4-methylcoumarin | pH 7.5, 25°C | Homo sapiens | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 9 | analysis of pH dependence of the reaction, overview | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000001 | - |
Ubiquitin aldehyde | below, pH 7.5, 25°C, inhibition kinectis | Homo sapiens | |
| 0.00014 | - |
ubiquitin | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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