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Literature summary for 3.4.19.12 extracted from
- Cloning and expression analysis of a Parkinson's disease gene, uch-L1, and its promoter in zebrafish (2003), Biochem. Biophys. Res. Commun., 312, 601-607.
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | the enzyme and the zebrafish can be utilized as an animal model for analysis of development of Parkinson's disease | Danio rerio |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Danio rerio |
| gene uch-L1, DNA and amino acid sequence determination and analysis | Homo sapiens |
| gene uch-L1, DNA and amino acid sequence determination and analysis, determination and cloning of the promoter sequence, promoter activity and expression analysis, overexpression of the gene and promoter in zebrafish embryos by microinjection | Danio rerio |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | gene uch-L1 is involved in development of Parkinson's disease | ? | - |
? |  |
| additional information | Danio rerio | uch-L1 may have an important role in the development of neuronal cells in early embryos as well as in the degeneration and disease of neuronal cells in late adult brain. The gene for ubiquitin C-terminal hydrolase L1 is associated with inherited forms of Parkinson's disease | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Danio rerio | - |
- |
- |
| Danio rerio | Q6YI49 | i.e. Danio rerio | - |
| Homo sapiens | P09936 | gene uch-L1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | - |
Danio rerio | - |
| embryo | spatiotemporal expression of gene uch-L1 mRNA during embryo development | Danio rerio | - |
| additional information | tissue-specific regulation of uhc-L1 gene expression, analysis, overview | Danio rerio | - |
| neuron | - |
Danio rerio | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | gene uch-L1 is involved in development of Parkinson's disease | Homo sapiens | ? | - |
? | |
| additional information | uch-L1 may have an important role in the development of neuronal cells in early embryos as well as in the degeneration and disease of neuronal cells in late adult brain. The gene for ubiquitin C-terminal hydrolase L1 is associated with inherited forms of Parkinson's disease | Danio rerio | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ubiquitin C-terminal hydrolase L1 | - |
Homo sapiens |
| ubiquitin C-terminal hydrolase L1 | - |
Danio rerio |
| UCH-L1 | - |
Homo sapiens |
| UCH-L1 | - |
Danio rerio |
| UCHL1 | - |
Homo sapiens |
| UCHL1 | - |
Danio rerio |
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