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Literature summary for 3.4.19.12 extracted from

  • Mullally, J.E.; Moos, P.J.; Edes, K.; Fitzpatrick, F.A.
    Cyclopentenone prostaglandins of the J series inhibit the ubiquitin isopeptidase activity of the proteasome pathway (2001), J. Biol. Chem., 276, 30366-30373.
    View publication on PubMed
Search for more literature for 3.4.19.12

Application

Application Comment Organism
pharmacology enzyme is a target for the development of antineoplastic agents Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
J series prostaglandins inhibition of the enzyme is involved in disruption of the proteasome pathway and leads to apoptosis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
polyubiquitin + H2O Homo sapiens disassembly of polyubiquitin, terminal step of the proteasome pathway, scheme ubiquitin
-
 ?
polyubiquitin + H2O Homo sapiens inhibition by prostaglandins of the J series leads to accumulation of polyubiquitins of MW around 250 kDa ubiquitin
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
polyubiquitin + H2O dissambly of polyubiquitin Homo sapiens ubiquitin
-
 ?
polyubiquitin + H2O disassembly of polyubiquitin, terminal step of the proteasome pathway, scheme Homo sapiens ubiquitin
-
 ?
polyubiquitin + H2O inhibition by prostaglandins of the J series leads to accumulation of polyubiquitins of MW around 250 kDa Homo sapiens ubiquitin
-
 ?